Surgical imaging of pancreatic cancer using polysaccharide-delivered near infrared fluorophores

Bowen Qi; Ayrianne J. Crawford; Nicholas E. Wojtynek; Michael A. Hollingsworth; Quan P. Ly; Aaron M. Mohs

doi:10.1117/12.2507008

7 March 2019 Surgical imaging of pancreatic cancer using polysaccharide-delivered near infrared fluorophores

Bowen Qi, Ayrianne J. Crawford, Nicholas E. Wojtynek, Michael A. Hollingsworth, Quan P. Ly, Aaron M. Mohs

Proceedings Volume 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V; 108620O (2019) https://doi.org/10.1117/12.2507008
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Improved methods to determine tumor localization and disease extension are critical factors in the management of pancreatic ductal adenocarcinoma (PDAC). Thus, contrast-enhanced fluorescence-guided detection of these lesions could improve the treatment of PDAC. A current limitation to fluorescence enhancement of PDAC is non-specific signal due to the clearance of the imaging dye, e.g. indocyanine green, like the liver, spleen or other local, intraperitoneal organs where metastatic spread may be present. We report surgical imaging agents that provide strong enhancement of PDAC compared to healthy tissue, but also have significantly reduced nonspecific background signal in clearance organs of the peritoneal cavity.

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Citation Download Citation

Bowen Qi, Ayrianne J. Crawford, Nicholas E. Wojtynek, Michael A. Hollingsworth, Quan P. Ly, and Aaron M. Mohs "Surgical imaging of pancreatic cancer using polysaccharide-delivered near infrared fluorophores", Proc. SPIE 10862, Molecular-Guided Surgery: Molecules, Devices, and Applications V, 108620O (7 March 2019); https://doi.org/10.1117/12.2507008

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