Visualization of the comprehensive birefringent information in polarization-sensitive optical coherence tomography
 (Conference Presentation)

Peijun Tang; Jingjiang Xu; Ruikang Wang

doi:10.1117/12.2511382

7 March 2019 Visualization of the comprehensive birefringent information in polarization-sensitive optical coherence tomography (Conference Presentation)

Peijun Tang, Jingjiang Xu, Ruikang Wang

Author Affiliations +

Proceedings Volume 10867, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII; 108670C (2019) https://doi.org/10.1117/12.2511382
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

We propose a novel method to visualize the integrated birefringence information for polarization-sensitive optical coherence tomography (PS-OCT) of biological tissue. A strategy that integrates the comprehensive birefringence property in a resultant image is introduced to obtain high contrast images of the birefringent samples. Then, color-based automatic segmentation of birefringent components from 3D scanned tissue volume is proposed to isolate the 3D network of the nerve bundles in a whole mouse brain. Experimental validation and demonstrations are given by imaging ex vivo mouse tail and whole brain tissues to show the usefulness of proposed comprehensive birefringent imaging and segmentation methods. These results sufficiently demonstrate the practical usefulness of the proposed strategy of using comprehensive polarization as the imaging parameter in the PS-OCT imaging of biological samples, indicating potential applications in both pre-clinical and clinical environments where accurate identification of birefringent tissue components is important, for example the nerve identification in delicate surgical remove of the diseased tissue mass in surgery.

Conference Presentation

Citation Download Citation

Peijun Tang, Jingjiang Xu, and Ruikang Wang "Visualization of the comprehensive birefringent information in polarization-sensitive optical coherence tomography (Conference Presentation)", Proc. SPIE 10867, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII, 108670C (7 March 2019); https://doi.org/10.1117/12.2511382

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KEYWORDS

Optical coherence tomography

Visualization

Tissues

Birefringence

Brain

Image segmentation

Nerve

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