Optimal NIR and SWIR optical parameters for absorption and SHG detecting deep tissue vessels in intestinal submucosa

Shirley Chan; Min Jing Zheng; Tiffany Chou; Stewart Russell; Robert R. Alfano

doi:10.1117/12.2510834

11 March 2019 Optimal NIR and SWIR optical parameters for absorption and SHG detecting deep tissue vessels in intestinal submucosa

Shirley Chan, Min Jing Zheng, Tiffany Chou, Stewart Russell, Robert R. Alfano

Author Affiliations +

Proceedings Volume 10873, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis; 1087319 (2019) https://doi.org/10.1117/12.2510834
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

In gastrointestinal endoscopic surgery, bleeding from the accidental resection of hidden vessels is a major complication, requiring immediate conversion to open surgery. Methods of visualizing occult vessels have been proposed using the FDA approved fluorescent dye Indocyanine green (ICG), but Native label-free fluorescence of the submucosa—present up till about 886 nm—prevents the use ICG in near-infrared (NIR) window I (700 nm to 900 nm). Instead, absorption imaging is preferred; the darker vessels are visible to 4.5 mm deep. Using data from Raman scattering, absorption, native fluorescence, SHG and the photon excitation fluorescence we investigate the spectral properties and propose optimal parameters for differentiation of blood vessels from surrounding tissue in a variety of tissue types in NIR window II (1000 nm to 1350 nm) and NIR window III (1550 nm to 1900 nm, the “Golden Window”) as a complement to absorption imaging.

Citation Download Citation

Shirley Chan, Min Jing Zheng, Tiffany Chou, Stewart Russell, and Robert R. Alfano "Optimal NIR and SWIR optical parameters for absorption and SHG detecting deep tissue vessels in intestinal submucosa", Proc. SPIE 10873, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 1087319 (11 March 2019); https://doi.org/10.1117/12.2510834

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KEYWORDS

Absorption

Luminescence

Near infrared

Optical properties

Short wave infrared radiation

Infrared imaging

Surgery

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