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4 March 2019 Optical fiber based light scattering detection in microfluidic droplets
Shulin Wohlfeil, Sundar Hengoju, Anne-Sophie Munser, Miguel Tovar, Oksana Shvydkiv, Martin Roth, Sven Schröder, Erik Beckert, Ramona Eberhardt, Andreas Tünnermann
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Proceedings Volume 10875, Microfluidics, BioMEMS, and Medical Microsystems XVII; 1087516 (2019) https://doi.org/10.1117/12.2509248
Event: SPIE BiOS, 2019, San Francisco, California, United States
Abstract
Droplet based microfluidic technology is a miniaturized platform for microbial analysis on picoliter scale. With its costefficiency, high-throughput and feasibility of complex handling protocols, droplet microfluidics is a favorable platform for applications such as microorganism screening or synthetic biology. Scattered-light-based microbial detection, in comparison to the widely used fluorescent-label-based approach, provides a contact-free and label-free, yet sensitive measuring solution. The angular dependency of scattered light delivers an elaborate information about the morphology and the physical properties, e.g. size and refractive index, of microbial samples. Due to the complexity and ambiguity of the droplet contents, an angle resolved scattered light detection system could provide powerful method for a label-free identification and quantification of the microbes in droplets. In this paper, a novel approach of light scattering measurement in Polydimethylsiloxane (PDMS) microfluidic chips is presented, engaging optical fibers for a light-scattering-based on-chip microbial detection. Optical fibers, with their fast readout and compact size, are very suitable for easier system integration towards flexible and versatile lab-on-a-chip applications.
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Shulin Wohlfeil, Sundar Hengoju, Anne-Sophie Munser, Miguel Tovar, Oksana Shvydkiv, Martin Roth, Sven Schröder, Erik Beckert, Ramona Eberhardt, and Andreas Tünnermann "Optical fiber based light scattering detection in microfluidic droplets", Proc. SPIE 10875, Microfluidics, BioMEMS, and Medical Microsystems XVII, 1087516 (4 March 2019); https://doi.org/10.1117/12.2509248
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KEYWORDS
Light scattering
Microfluidics
Optical fibers
Scatter measurement
System integration
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