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27 February 2019 Co-registered photoacoustic and ultrasound real-time imaging of colorectal cancer: ex-vivo studies
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Colorectal cancer is the second most common malignancy diagnosed globally. Critical need exists for imaging and diagnosis of rectal tumors for both staging and therapeutic response evaluations. We have conducted a pilot study to image and characterize colorectal masses using a real-time co-registered photoacoustic (PAT) and ultrasound (US) system. A total of 8 tissue samples including pre- and post-treatment colorectal cancer, polyps have studied. Four different wavelengths (730, 780, 800, 830 nm) were used to illuminate the sample and a scanning stage was used to scan a large area and obtain a sequence of B-scans. For the pre-treatment colorectal cancer, photoacoustic images have shown significantly higher vascular level than neighbor benign regions of the same sample. The pre-treatment colorectal cancer PAT signal level is also higher than polyps and post-treatment colorectal cancer. Additionally, the quantitative features extracted from PAT and US power spectrum such as spectral slope, mid-band fit and zero MHz intercept have shown statistical significance between pre-treatment colorectal cancer and other 3 categories using t-test. Our initial results have demonstrated that PAT/US has a great potential to reveal tumor angiogenesis development or residual tumors after treatment.
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Guang Yang, Eghbal Amidi, William Chapman Jr., Sreyankar Nandy, Atahar Mostafa, Heba Abdelal, Zahra Alipour, Deyali Chatterjee, Matthew Mutch, and Quing Zhu "Co-registered photoacoustic and ultrasound real-time imaging of colorectal cancer: ex-vivo studies", Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 108784K (27 February 2019);

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