Monitoring vascular targeted PDT response with multimode optical imaging

Yi Shen; Fuqiang Liang; Yanhui Niu; Huiyun Lin; Ying Gu; Brian C. Wilson; Buhong Li

doi:10.1117/12.2513578

7 March 2019 Monitoring vascular targeted PDT response with multimode optical imaging

Yi Shen, Fuqiang Liang, Yanhui Niu, Huiyun Lin, Ying Gu, Brian C. Wilson, Buhong Li

Proceedings Volume 10879, Biophotonics and Immune Responses XIV; 1087906 (2019) https://doi.org/10.1117/12.2513578
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Vascular targeted photodynamic therapy (V-PDT) has shown satisfied efficiency in treating vascular-related diseases including age-related macular degeneration, port-wine stains (PWS), and prostate cancer. Its efficacy is a complex function of photosensitizer (PS) uptake, oxygen concentration, PS-activating light dose and tissue optical properties. In order to non -invasively monitor PS distribution and photobleaching, blood vessel contraction and blood flow velocity for V-PDT response, a multimode optical imaging (MOI) system was developed to capture PS fluorescence image, narrow band image and laser speckle image, respectively. V-PDT in vivo studies were performed, which suggests that our MOI system is capable of monitoring dynamic response during V-PDT treatment.

Citation Download Citation

Yi Shen, Fuqiang Liang, Yanhui Niu, Huiyun Lin, Ying Gu, Brian C. Wilson, and Buhong Li "Monitoring vascular targeted PDT response with multimode optical imaging", Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 1087906 (7 March 2019); https://doi.org/10.1117/12.2513578

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KEYWORDS

Laser speckle contrast imaging

Blood vessels

Luminescence

Picosecond phenomena

Photodynamic therapy

Blood circulation

Imaging systems

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