Design of a multi-material loaded soft tissue phantom for the estimation of phase maps using a single exposure x-ray phase retrieval method

Muhammad U. Ghani; Aimin Yan; Yuchen Qui; Wei Chen; Xizeng Wu; Hong Liu

doi:10.1117/12.2511196

7 March 2019 Design of a multi-material loaded soft tissue phantom for the estimation of phase maps using a single exposure x-ray phase retrieval method

Muhammad U. Ghani, Aimin Yan, Yuchen Qui, Wei Chen, Xizeng Wu, Hong Liu

Author Affiliations +

Proceedings Volume 10879, Biophotonics and Immune Responses XIV; 108790L (2019) https://doi.org/10.1117/12.2511196
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

An essential goal of x-ray phase-sensitive imaging is to provide quantitative information such as tissue’s phase maps and electron densities. Various phase retrieval methods have been developed for this task. One such retrieval method-based phase-attenuation duality (PAD) principle and requires only a single exposure for the phase retrieval. We have developed a multi-material loaded soft tissue phantom that can be used for the investigate the accuracy of the PAD-based method in retrieving the phase maps and electron tissue densities. The phantom consists of five inserts; muscle, lung, breast, adipose and Polymethyl methacrylate (PMMA). Each insert had a diameter of 5 mm and a length of 8.2 mm, respectively. The inserts were fitted in a 3D printed circular disk. An x-ray phase sensitive prototype was used to image a PMMA slab for testing to compare the accuracy of the retrieved phase maps with the theoretically estimated values. With the PAD-based method, the average phase value was about -200 radians while the theoretical estimate was -185 radians. A comprehensive future study will be conducted with the newly design phantom to demonstrate further the potential benefits of using x-ray phase-sensitive imaging for the quantification and identification of tissues.

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Citation Download Citation

Muhammad U. Ghani, Aimin Yan, Yuchen Qui, Wei Chen, Xizeng Wu, and Hong Liu "Design of a multi-material loaded soft tissue phantom for the estimation of phase maps using a single exposure x-ray phase retrieval method", Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 108790L (7 March 2019); https://doi.org/10.1117/12.2511196

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