Evaluation of both antioxidant and anti-inflammatory activity of traditional Chinese Huzhentongfeng Extract

Zi-cong Wu; Zhen-ling Zhao; Tong-sheng Chen; Yi-fei Wang; Zhi-ping Wang

doi:10.1117/12.2508590

7 March 2019 Evaluation of both antioxidant and anti-inflammatory activity of traditional Chinese Huzhentongfeng Extract

Zi-cong Wu, Zhen-ling Zhao, Tong-sheng Chen, Yi-fei Wang, Zhi-ping Wang

Author Affiliations +

Proceedings Volume 10879, Biophotonics and Immune Responses XIV; 108790W (2019) https://doi.org/10.1117/12.2508590
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Huzhentongfeng (HZTF) is a compound extract developed by Guangzhou (Jinan) Biomedical Research and Development Center for treating gout. To investigate the antioxidative activity and anti-inflammatory activity of HZTF, the scavenging activity of hydroxyl radical, ferrous ions chelating ability and ferric reducing antioxidant power (FRAP) were used as indicators to evaluate the antioxidant activity and the lipopolysaccharide(LPS)-induced RAW264.7 macrophages were used to assess its anti-inflammatory activity. The results showed that HZTF had certain antioxidant activity, the IC50 values of HZTF in hydroxyl radical scavenging activity and ferrous ions chelating ability are 163.83 ± 10.49 and 899.72 ± 20.98 μg/mL, respectively and the FRAP value of HZTF are 8.97 ± 0.63 mol FeSO4/g. Moreover, HZTF significantly reduced IL-1β, IL-6, TNF-α, iNOS expression and NO production in LPS-induced RAW264.7 macrophages (P < 0.05), which demonstrate that HZTF have good potential to be developed as antioxidant or anti-inflammatory medicines.

Citation Download Citation

Zi-cong Wu, Zhen-ling Zhao, Tong-sheng Chen, Yi-fei Wang, and Zhi-ping Wang "Evaluation of both antioxidant and anti-inflammatory activity of traditional Chinese Huzhentongfeng Extract", Proc. SPIE 10879, Biophotonics and Immune Responses XIV, 108790W (7 March 2019); https://doi.org/10.1117/12.2508590

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available