Digital optical microscope (housing inside biosafety cabinet): a promising imaging technology for micro- and cell-biology, and histopathology

Anamika Elizabeth Kujur; Rinsa S. R.; Mayanglambam Suheshkumar Singh

doi:10.1117/12.2502117

22 March 2019 Digital optical microscope (housing inside biosafety cabinet): a promising imaging technology for micro- and cell-biology, and histopathology

Anamika Elizabeth Kujur, Rinsa S. R., Mayanglambam Suheshkumar Singh

Author Affiliations +

Proceedings Volume 10948, Medical Imaging 2019: Physics of Medical Imaging; 109483T (2019) https://doi.org/10.1117/12.2502117
Event: SPIE Medical Imaging, 2019, San Diego, California, United States

Abstract

Conventional laboratory activities for research studies, more specifically in Biology and histopathology, involves back and forth movement of biological or tissue specimen all around the laboratory workspace - from Biosafety Cabinet (BSC) to workbench of microscopy imaging unit. This mobility imposes a serious concern of contamination of the biological specimen. We study design and develop of an optical microscopic imaging system - that can be adapted inside BSC - which remains as a challenge from technological aspects. This (automated) system with motion control in all 3-directions facilitates recording as well as observation of the biological procedure (in real time) being performed inside BSC. Experimental validation studies were carried out in a diverse biological specimen and demonstrate that this imaging technology facilitates study of miniscule biological specimen (cells and bacteria) not only easy but also enable to undertake sophisticated biological/clinical procedures.

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Anamika Elizabeth Kujur, Rinsa S. R., and Mayanglambam Suheshkumar Singh "Digital optical microscope (housing inside biosafety cabinet): a promising imaging technology for micro- and cell-biology, and histopathology", Proc. SPIE 10948, Medical Imaging 2019: Physics of Medical Imaging, 109483T (22 March 2019); https://doi.org/10.1117/12.2502117

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KEYWORDS

Imaging systems

Microscopes

Objectives

Microscopy

Contamination

Tissue optics

Biomedical optics

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