Generation of retinal OCT images with diseases based on cGAN

Xuewei Zha; Fei Shi; Yuhui Ma; Weifang Zhu; Xinjian Chen

doi:10.1117/12.2510967

15 March 2019 Generation of retinal OCT images with diseases based on cGAN

Xuewei Zha, Fei Shi, Yuhui Ma, Weifang Zhu, Xinjian Chen

Proceedings Volume 10949, Medical Imaging 2019: Image Processing; 1094924 (2019) https://doi.org/10.1117/12.2510967
Event: SPIE Medical Imaging, 2019, San Diego, California, United States

Abstract

Data imbalance is a classic problem in image classification, especially for medical images where normal data is much more than data with diseases. To make up for the absence of disease images, methods which can generate retinal OCT images with diseases from normal retinal images are investigated. Conditional GANs (cGAN) have shown significant success in natural images generation, but the applications for medical images are limited. In this work, we propose an end-to-end framework for OCT image generation based on cGAN. The new structural similarity index (SSIM) loss is introduced so that the model can take the structure-related details into consideration. In experiments, three kinds of retinal disease images are generated. The generated images assume the natural structure of the retina and thus are visually appealing. The method is further validated by testing the classification performance trained by the generated images.

Citation Download Citation

Xuewei Zha, Fei Shi, Yuhui Ma, Weifang Zhu, and Xinjian Chen "Generation of retinal OCT images with diseases based on cGAN", Proc. SPIE 10949, Medical Imaging 2019: Image Processing, 1094924 (15 March 2019); https://doi.org/10.1117/12.2510967

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