Reproducibility evaluation of SLANT whole brain segmentation across clinical magnetic resonance imaging protocols

Yunxi Xiong; Yuankai Huo; Jiachen Wang; L. Taylor Davis; Maureen McHugo; Bennett A. Landman

doi:10.1117/12.2512561

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15 March 2019 Reproducibility evaluation of SLANT whole brain segmentation across clinical magnetic resonance imaging protocols

Yunxi Xiong, Yuankai Huo, Jiachen Wang, L. Taylor Davis, Maureen McHugo, Bennett A. Landman

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Proceedings Volume 10949, Medical Imaging 2019: Image Processing; 109492V (2019) https://doi.org/10.1117/12.2512561
Event: SPIE Medical Imaging, 2019, San Diego, California, United States

Abstract

Whole brain segmentation on structural magnetic resonance imaging (MRI) is essential for understanding neuroanatomical-functional relationships. Traditionally, multi-atlas segmentation has been regarded as the standard method for whole brain segmentation. In past few years, deep convolutional neural network (DCNN) segmentation methods have demonstrated their advantages in both accuracy and computational efficiency. Recently, we proposed the spatially localized atlas network tiles (SLANT) method, which is able to segment a 3D MRI brain scan into 132 anatomical regions. Commonly, DCNN segmentation methods yield inferior performance under external validations, especially when the testing patterns were not presented in the training cohorts. Recently, we obtained a clinically acquired, multi-sequence MRI brain cohort with 1480 clinically acquired, de-identified brain MRI scans on 395 patients using seven different MRI protocols. Moreover, each subject has at least two scans from different MRI protocols. Herein, we assess the SLANT method’s intra- and inter-protocol reproducibility. SLANT achieved less than 0.05 coefficient of variation (CV) for intra-protocol experiments and less than 0.15 CV for inter-protocol experiments. The results show that the SLANT method achieved high intra- and inter- protocol reproducibility.

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Yunxi Xiong, Yuankai Huo, Jiachen Wang, L. Taylor Davis, Maureen McHugo, and Bennett A. Landman "Reproducibility evaluation of SLANT whole brain segmentation across clinical magnetic resonance imaging protocols", Proc. SPIE 10949, Medical Imaging 2019: Image Processing, 109492V (15 March 2019); https://doi.org/10.1117/12.2512561

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