Rapid bacteria detection using a portable magnetoelastic biosensor system (Conference Presentation)

Shin Horikawa; I-Hsuan Chen; Yuzhe Liu; Songtao Du; Bryan A. Chin

doi:10.1117/12.2520242

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14 May 2019 Rapid bacteria detection using a portable magnetoelastic biosensor system (Conference Presentation)

Shin Horikawa, I-Hsuan Chen, Yuzhe Liu, Songtao Du, Bryan A. Chin

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Proceedings Volume 11016, Sensing for Agriculture and Food Quality and Safety XI; 110160A (2019) https://doi.org/10.1117/12.2520242
Event: SPIE Defense + Commercial Sensing, 2019, Baltimore, Maryland, United States

Abstract

This paper presents a portable magnetoelastic (ME) biosensor system that enables rapid, on-site detection of pathogenic bacteria. The system utilizes a patented portable resonant frequency analyzer and two 1 mm long ME biosensors (biosensors coated with and without phage binding a specific pathogen) enabling real-time measurement of resonant frequency changes. By comparing the response of the biosensors, the presence of the specific pathogen can be detected. In this work, detection of Salmonella Typhimurium cells was demonstrated, and it was found that down to 2,500 cfu can be detected in less than 10 min. The detection limit can be improved by using a smaller sensor (e.g., 500 um long sensors) and an optimal chamber design increasing the probability of bacterial cells striking the biosensor surface.

Conference Presentation

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Shin Horikawa, I-Hsuan Chen, Yuzhe Liu, Songtao Du, and Bryan A. Chin "Rapid bacteria detection using a portable magnetoelastic biosensor system (Conference Presentation)", Proc. SPIE 11016, Sensing for Agriculture and Food Quality and Safety XI, 110160A (14 May 2019); https://doi.org/10.1117/12.2520242

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