Optical coherence elastography as a new method for estimation of chemotherapy efficacy on triple-negative breast cancer in the experiment

Anton A. Plekhanov; Marina A. Sirotkina; Alexander A. Sovetsky; Ekaterina V. Gubarkova; Elena B. Kiseleva; Vladimir Y. Zaitsev; Lev A. Matveev; Alexander L. Matveyev; Sergey S. Kuznetsov; Elena V. Zagaynova; Natalia D. Gladkova

doi:10.1117/12.2521571

3 June 2019 Optical coherence elastography as a new method for estimation of chemotherapy efficacy on triple-negative breast cancer in the experiment

Anton A. Plekhanov, Marina A. Sirotkina, Alexander A. Sovetsky, Ekaterina V. Gubarkova, Elena B. Kiseleva, Vladimir Y. Zaitsev, Lev A. Matveev, Alexander L. Matveyev, Sergey S. Kuznetsov, Elena V. Zagaynova, Natalia D. Gladkova

Author Affiliations +

Proceedings Volume 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine; 1106506 (2019) https://doi.org/10.1117/12.2521571
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation

Abstract

Normal and pathological tissues are different in their elastic properties. Thus, elastic characteristics of tissues can serve as an additional diagnostic marker to distinguish altered tissues. A number of studies have demonstrated advantages of using optical coherent tomography in clinical practice and research. Here we report the application of optical coherence elastography (OCE) for studying elastic properties of murine breast cancer 4T1. It is known that 4T1 model is convenient for in vivo tumor imaging and is highly relevant to studies of tumor process. In this study the therapy was performed with a cytostatic chemotherapeutic drug cisplatin. We developed the protocol of compressional OCT elastography for long-term in vivo monitoring of tumor response to anti-tumor therapy. The ear tumor model was chosen as optimal for this task. Histological analysis demonstrated good agreement with OCE-based stiffness-mapping results.

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Anton A. Plekhanov, Marina A. Sirotkina, Alexander A. Sovetsky, Ekaterina V. Gubarkova, Elena B. Kiseleva, Vladimir Y. Zaitsev, Lev A. Matveev, Alexander L. Matveyev, Sergey S. Kuznetsov, Elena V. Zagaynova, and Natalia D. Gladkova "Optical coherence elastography as a new method for estimation of chemotherapy efficacy on triple-negative breast cancer in the experiment", Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 1106506 (3 June 2019); https://doi.org/10.1117/12.2521571

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