Comparison of elastic properties of tissue samples in various pathological states using optical coherence elastography

Ekaterina V. Gubarkova; Alexander A. Sovetsky; Vladimir Yu. Zaitsev; Lev A. Matveev; Alexander L. Matveyev; Dmitry A. Vorontsov; Lydia B. Timofeeva; Elena B. Kiseleva; Alexey Yu. Vorontsov; Irina A. Kuznetsova; Natalia D. Gladkova

doi:10.1117/12.2521529

3 June 2019 Comparison of elastic properties of tissue samples in various pathological states using optical coherence elastography

Ekaterina V. Gubarkova, Alexander A. Sovetsky, Vladimir Yu. Zaitsev, Lev A. Matveev, Alexander L. Matveyev , Dmitry A. Vorontsov, Lydia B. Timofeeva, Elena B. Kiseleva, Alexey Yu. Vorontsov, Irina A. Kuznetsova, Natalia D. Gladkova

Author Affiliations +

Proceedings Volume 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine; 110650D (2019) https://doi.org/10.1117/12.2521529
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation

Abstract

Elastic properties of soft biological tissues may reflect their functional state and be a sensitive indicator of important pathological processes occurring in them. Using compressional optical coherent elastography (OCE) we revealed significant differences not only in the value of the Young modulus, but also in the character of elastic responses of biological tissues in different pathological states (including such key states as inflammatory, oncological and degenerative processes) in ex vivo human tissues. Here, we demonstrate a bright example of such qualitatively and quantitatively different trends: unlike breast cancer characterized by strongly elevated (in comparison with norm) stiffness that pronouncedly increases with compression, stiffness of pelvic organ prolapse is strongly decreased and weakly varies with compression.

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Ekaterina V. Gubarkova, Alexander A. Sovetsky, Vladimir Yu. Zaitsev, Lev A. Matveev, Alexander L. Matveyev , Dmitry A. Vorontsov, Lydia B. Timofeeva, Elena B. Kiseleva, Alexey Yu. Vorontsov, Irina A. Kuznetsova, and Natalia D. Gladkova "Comparison of elastic properties of tissue samples in various pathological states using optical coherence elastography", Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 110650D (3 June 2019); https://doi.org/10.1117/12.2521529

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