Comparative in-vivo and in-vitro study of blood rheological properties in patients with coronary heart disease with laser-optic techniques

Yury I. Gurfinkel; Andrei E. Lugovtsov; Petr B. Ermolinskiy; Elena P. Pavlikova; Larisa I. Diachuk; Alexander V. Priezzhev

doi:10.1117/12.2523896

3 June 2019 Comparative in-vivo and in-vitro study of blood rheological properties in patients with coronary heart disease with laser-optic techniques

Yury I. Gurfinkel, Andrei E. Lugovtsov, Petr B. Ermolinskiy, Elena P. Pavlikova, Larisa I. Diachuk, Alexander V. Priezzhev

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Proceedings Volume 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine; 110650U (2019) https://doi.org/10.1117/12.2523896
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation

Abstract

Studying the reversible aggregation of red blood cells (RBC), which is one of the main factors determining the blood microcirculation is of importance for modern cardiology because the widespread application of different antiplatelet agents and anticoagulants in clinical practice may affect the blood rheology also via the alteration of RBC aggregation. Administration of the antiplatelet and anticoagulants agents into blood is based on general assumptions about the average doses of the drug, which often do not fully comply with the requirements of the personalized medicine. In this work, we compare the blood aggregation properties measured by laser aggegometry techniques in-vitro in blood samples with the properties of blood rheology measured with digital capillaroscopy in-vivo in the nail beds capillaries of patients suffering from the coronary heart disease (CHD). We demonstrate the impairment of these properties and high correlation of their alterations for patients suffering from the CHD with different stages of rheology disorders. Good agreement between the results obtained with the used diagnostic techniques, laser aggregometry, laser tweezers and digital capillaroscopy, and their applicability for the diagnostics of abnormalities of rheological properties of blood are demonstrated.

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Yury I. Gurfinkel, Andrei E. Lugovtsov, Petr B. Ermolinskiy, Elena P. Pavlikova, Larisa I. Diachuk, and Alexander V. Priezzhev "Comparative in-vivo and in-vitro study of blood rheological properties in patients with coronary heart disease with laser-optic techniques", Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 110650U (3 June 2019); https://doi.org/10.1117/12.2523896

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KEYWORDS

Blood

Capillaries

Blood circulation

Optical tweezers

In vitro testing

Heart

In vivo imaging

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