The role of the meningeal lymphatic in the brain clearing

M. Klimova; A. Dubrovsky; E. Duarte Torres; A. Abdurashitov; A. Shirokov; A. Terskov; A. Khorovodov; E. Sarantseva; T. Iskra; O. V. Semyachkina-Glushkovskaya

doi:10.1117/12.2524451

3 June 2019 The role of the meningeal lymphatic in the brain clearing

M. Klimova , A. Dubrovsky, E. Duarte Torres , A. Abdurashitov, A. Shirokov, A. Terskov, A. Khorovodov, E. Sarantseva, T. Iskra, O. V. Semyachkina-Glushkovskaya

Author Affiliations +

Proceedings Volume 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions; 110670Z (2019) https://doi.org/10.1117/12.2524451
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation

Abstract

Here in ex vivo (confocal imaging) and in vivo (optical coherent tomography) experiments on adult mice, we clearly demonstrate that the meningeal lymphatic drainage is an important mechanism for the brain clearing that might be also pathway for the brain clearing from metabolites and waste products that requests further detailed studies. Photodynamic effects stimulate the meningeal/cervical drainage opening new ideas for development of novel methods of activation of brain clearing that might be progressive strategies in therapy of neurovegetative diseases.

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M. Klimova , A. Dubrovsky, E. Duarte Torres , A. Abdurashitov, A. Shirokov, A. Terskov, A. Khorovodov, E. Sarantseva, T. Iskra, and O. V. Semyachkina-Glushkovskaya "The role of the meningeal lymphatic in the brain clearing", Proc. SPIE 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 110670Z (3 June 2019); https://doi.org/10.1117/12.2524451

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KEYWORDS

Lymphatic system

Brain

Blood brain barrier

Optical coherence tomography

Confocal microscopy

In vivo imaging

Nanorods

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