Laser-stimulated lymphangion activity in rat mesentery

Elena S. Stiukhina; Nikolay I. Lvov; Evgeniya A. Kozlova; Grigory E. Brill; Dmitry E. Postnov

doi:10.1117/12.2523313

17 June 2019 Laser-stimulated lymphangion activity in rat mesentery

Elena S. Stiukhina, Nikolay I. Lvov, Evgeniya A. Kozlova, Grigory E. Brill, Dmitry E. Postnov

Proceedings Volume 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions; 1106715 (2019) https://doi.org/10.1117/12.2523313
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation

Abstract

Spontaneous contractile activity is the most important property of small lymphatic vessels since it ensures the fulfillment of their main function - the propulsion of lymph in the direction from the lymphatic capillaries to the lymph nodes. Experimental research and diagnostic assessment of the state of the contractile mechanisms of the structural element of the lymphatic vessel - lymphangion - require, among other things, reliable non-destructive methods to start its contraction cycle at the will of the researcher. In this paper, we propose to use as a tool a highly localized laser radiation focused on the cells of the vascular wall of the lymphangion. We implement this method using laser with a wavelength of 405 nm focused to a spot with a diameter of 10-14 micrometres. The obtained results show a reliable and reproducible response of the lymphangion in the form of a single contraction or their sequence. We also compare the characteristics of such induced contractions with a case of spontaneous activity.

Citation Download Citation

Elena S. Stiukhina, Nikolay I. Lvov, Evgeniya A. Kozlova, Grigory E. Brill, and Dmitry E. Postnov "Laser-stimulated lymphangion activity in rat mesentery", Proc. SPIE 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 1106715 (17 June 2019); https://doi.org/10.1117/12.2523313

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