Simulation study of Compton camera imaging for human head phantom proton therapy

Zhiyang Yao; Zhiqiang Chen; Yongshun Xiao

doi:10.1117/12.2523274

10 May 2019 Simulation study of Compton camera imaging for human head phantom proton therapy

Zhiyang Yao, Zhiqiang Chen, Yongshun Xiao

Proceedings Volume 11068, Second Symposium on Novel Technology of X-Ray Imaging; 110680I (2019) https://doi.org/10.1117/12.2523274
Event: Second Symposium on Novel Technology of X-Ray Imaging, 2018, Hefei, China

Abstract

Prompt gamma ray (PG) imaging based on Compton camera (CC) has been proposed to realize in vivo verification during the proton therapy. However, due to the inherent geometrical complexity of Compton camera data, PG imaging can be time-consuming and difficult to reconstruct in real-time, while using standard techniques such as filtered back-projection (FBP) or list-mode maximum likelihood-expectation maximization (LM-MLEM). In addition, the imaging quality and spatial resolution of the reconstructed PG images is seriously limited by the finite energy and spatial resolution of CC, as well as the Doppler broaden effect. In this paper, we investigate the performance of in vivo verification via PG imaging with a three-stage Cadmium Zinc Telluride (CZT) pixelated Compton camera during the proton therapy for human head. We demonstrated the real-time PG imaging approach by using Monte Carlo back-projection (MC-BP) and triple events. The prompt gammas were induced by a 69MeV ~ 86 MeV proton pencil beam irradiating the human head phantom, which were simulated by using Geant4 toolkit. The results show that the reconstructions with Compton camera imaging realized nearly real-time PG imaging with a good resolution recovery, as well as provided the accurate estimation of in-vivo verification, thus demonstrating the feasibility in PG-based in-vivo proton range verification with CC.

Citation Download Citation

Zhiyang Yao, Zhiqiang Chen, and Yongshun Xiao "Simulation study of Compton camera imaging for human head phantom proton therapy", Proc. SPIE 11068, Second Symposium on Novel Technology of X-Ray Imaging, 110680I (10 May 2019); https://doi.org/10.1117/12.2523274

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