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The papers in this volume were part of the technical conference cited on the cover and title page. Papers were selected and subject to review by the editors and conference program committee. Some conference presentations may not be available for publication. Additional papers and presentation recordings may be available online in the SPIE Digital Library at SPIEDigitalLibrary.org. The papers reflect the work and thoughts of the authors and are published herein as submitted. The publisher is not responsible for the validity of the information or for any outcomes resulting from reliance thereon. Please use the following format to cite material from these proceedings: Author(s), “Title of Paper,” in 17th International Photodynamic Association World Congress, edited by Tayyaba Hasan, Proceedings of SPIE Vol. 11070 (SPIE, Bellingham, WA, 2019) Seven-digit Article CID Number. ISSN: 0277-786X ISSN: 1996-756X (electronic) ISBN: 9781510628335 ISBN: 9781510628342 (electronic) Published by SPIE P.O. Box 10, Bellingham, Washington 98227-0010 USA Telephone +1 360 676 3290 (Pacific Time) · Fax +1 360 647 1445 Copyright © 2019, Society of Photo-Optical Instrumentation Engineers. Copying of material in this book for internal or personal use, or for the internal or personal use of specific clients, beyond the fair use provisions granted by the U.S. Copyright Law is authorized by SPIE subject to payment of copying fees. The Transactional Reporting Service base fee for this volume is $21.00 per article (or portion thereof), which should be paid directly to the Copyright Clearance Center (CCC), 222 Rosewood Drive, Danvers, MA 01923. Payment may also be made electronically through CCC Online at copyright.com. Other copying for republication, resale, advertising or promotion, or any form of systematic or multiple reproduction of any material in this book is prohibited except with permission in writing from the publisher. The CCC fee code is 0277-786X/19/$21.00. Printed in the United States of America by Curran Associates, Inc., under license from SPIE. Publication of record for individual papers is online in the SPIE Digital Library.
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AuthorsNumbers in the index correspond to the last two digits of the seven-digit citation identifier (CID) article numbering system used in Proceedings of SPIE. The first five digits reflect the volume number. Base 36 numbering is employed for the last two digits and indicates the order of articles within the volume. Numbers start with 00, 01, 02, 03, 04, 05, 06, 07, 08, 09, 0A, 0B…0Z, followed by 10-1Z, 20-2Z, etc. A. Canevari, Renata, AF Abirached, H., 3J Abi-Rached, Henry, 5L Abrahamse, H., 1V Acar, Havva Y., 13 Acedo, P., 45, 97 Akkad, Rias, 2M Al-Akkad, Walid, 6K Alves, Fernanda, 8S Amaro, F., 8C Anand-Apte, Bela, 1N Anayo, Lizette, 6R Andersen, R., 8J Arthuzo, G., B6 Atenco-Cuautle, JC, A0, A1 Baert, Gregory, 2M, 30, 5P, 64, 85 Bagnato, Vanderlei Salvador, 6Q, 6Z, 88, 8K, 8S, B6 Banerjee, S. M., 97 Baptista, Alessandra, 8F, BY Baptista, Maurício S., 8L Baptista-Hon, Daniel, 6E Barnes, Klressa D., 46 Batoki, Julia C., 1N Baydoun, M., 5P Beaugé, L., 12 Bezdetnaya, Lina, 1P Blanco, Kate Cristina, 88 Bouramtane, S., 9A Boyle, Ross W., 9I Brader, Nadine, AP Bregier, F., 9A Bretin, L., 9A Busch, Theresa M., B0, BI Buzzá, Hilde Harb, 6Z, B6 Callaghan, Susan, 9I Camarero, Núria, 9H Cang, Wei, 27 Cengel, Keith, B0 Chaleix, V., 9A Chaves Silva Carvalho, Isabel, AF Chen, Guiqin, 23, 73 Chen, Juan, 4J Chen, Mingliang, 0V Chen, Xiang, 0V Chen, Zhou, 7T Cheng, LeNan, 23, 73 Cheng, Mengxing, 27 Chesta, C. A., 12 Cho, Won, 2B Cieślar, Grzegorz, A2, A3, B1, B2 Corrêa, Thaila Quatrini, 88, 8K Curnow, Alison, 2Y, 6R Czuba, Zenon, A3 Dailton G. O. Moraes, Carlos, AF Damen, Martha P. F., 4J Damrongrungruang, Teerasak, 9J, 9L Damyeh, Maral Seidi, 0O Davidson, Brian R., 13, 4R, 6K de Castro, Cynthia Aparecida, 6Z de Faria Souza, Roberta Kelly, AF de Freitas, Laura M., 8L de Oliveira, Kleber Thiago, 8K de Souza, Clovis Wesley Oliveira, 8K Deleporte, Pascal, 2M, 5L, 5P, 64 Delgado-López, MG, A0, A1 Delhem, N., 5P Descalzo, A. B., 8C DeWitt, John, 5Y Di, Wen, 27 Dimofte, Andreea, B0, BI Dupont, C., 4Q, 64 El Sheikh, S., 97 Fang, Tian-wen, 7X Ferreira Strixino, Juliana, AF Filatov, Mikhail A., 9I Filonenko, E. V., 81 Fong, Wing-Ping, 2V Fukuhara, Hideo, 2H Garcez, Aguinaldo S., 8W Garcia-Sampedro, A., 45 Gerrard, G., 97 Godoi, Bruno Henrique, AF Gómez-Mendoza, M., 8C Gomila, Alexandre M. J., 9H Gorostiza, Pau, 9H Goryajnov, Sergey, 6B Grachev, Pavel, 6B Griffin, Robert J., 46 Grigorievykh, N. I., 81 Gu, Li-Ying, 27 Gyenge, Emina Besic, AP Halašková, Marie, 9M Hales, Tim, 6E Hamoudi, R., 97 Hanazaki, Kazuhiro, 2H Harmatys, Kara M., 4J Hashemkhani, Mahshid, 13 Hewitt, Molly, 6E Hirai, Noriko, 2L Hommel, Theresa, 5L Hong, Zu-Bei, 27 Höpfner, Michael, AG Hossain-Ibrahim, Kismet, 6E Huang, Jingyi, 7T Huang, Kai, 0V Ibarra, L. E., 12 Inada, Natalia Mayumi, 6Z, 88, 8S Inaji, Motoki, 1H Inoue, Keiji, 2H Ishibashi, Kei, 2L Ishii, Kenji, 1H Jenkins, Samir V., 46 Jensen, Grant J., 8W Jiang, Xian, 7G, 96 Joniová, Jaroslava, BZ Jordan, Kevin J., AV Kaleta-Richter, Marta, A2 Kaplan, Mohammed, 8W Kaprin, A. D., 81 Kawczyk-Krupka, Aleksandra, A2, A3, B1, B2 Kazebayashi, Yoshihiro, 2L Keshtgar, M. R. S., 97 Kessel, David, 14, 2B Kim, H.-R. C., 2B Kim, Michele M., B0 Kitada, Masahiro, 2L Kojima, Miho, 95 Kollár, Jan, 9M Kouli, Omar, 6E Kruger, C. A., 1V Kumar, A., 5P Kurachi, Cristina, 6Q, 88, 8S Kuster, Niels, AP Kustov, Daniil, 6B Labib, Peter L., 13, 4R, 6K Lai, Hung Wei, 6I, A4 Lamberti, María Julia, 3L Lassalle, Henri-Pierre, 1P Latos, Wojciech, A2, A3, B1, B2 Lecomte, Fabienne, 30, 3J, 5L, 64, 85 Leger, D.-Y., 9A Leroux, B., 5P Li, Andrew C., BI Li, Dan-chen, 7X Li, Fangfang, 0V Li, Jinmao, 0V Liagre, B., 9A Libergoli, Michela, 9H Linkov, Kirill, 6B Liu, Guangzhi, 23, 73 Liu, Lian, 7G, 96 Loebel, N., 8J Loizidou, Marilena, 13 Lombardi, Wellington, 6Z Loschenov, Victor, 6B Lu, XiaoLi, 23, 73 Luk, John M., 2V Lum, Yick-Liang, 2V Maake, Caroline, AP Maccioni, Mariana, 3L Macháček, Miloslav, 9M MacRobert, Alexander J., 13, 45, 4R, 6K, 97 Maehara, Taketoshi, 1H Magnussen, Anette, 6R Mahamed, I., 45 Maire, Cyril, 3J, 5L Makhseed, Saad, 9M Maklygina, Yuliya, 6B Mangkhalathon, Ampika, 9J Mao, Bing, 23, 73 Marques, Ricardo H., 8F Martin, A. A., BY Martins, Laura Cristina Angioletto, 8K Matera, Carlo, 9H Meecham, A., 97 Meller, D., 8J Mentucci, Fátima María, 3L Mereddy, Ram, 0O Mertas, Anna, A3 Miedzybrodzka, Anna, A2 Minami, Yoshinori, 2L Mizutani-Morita, Reiko, 95 Mokwena, M. G., 1V Moore, Corey, AV Morales, Noppawan Phumala, 9J Morales, O., 5P Mordon, Serge R., 2M, 30, 3J, 4Q, 5L, 5P, 64, 85 Moriyama, Lilian Tan, 6Q Morkmued, Supawich, 9J Mortier, Laurent, 30, 3J, 5L, 85 Munck, Camille, 2M Mundi, Neil, AV Murbach, Manuel, AP Nakajima, Motowo, 2H, 6I, A4 Nakayama, Taku, 2H Nariai, Tadashi, 1H Navarro, Ricardo S., 8F Netzel, Michael E., 0O Ney, A., 45 Ng, Dennis K. P., 2V Nitzsche, Bianca, AG Nong, Xiang, 7X Núñez, Silvia Cristina, 48, 8F, 8W, BY Ogbodu, Racheal O., AG Ogura, Shun-ichiro, 2H, 6I, A4 Ohsaki, Yoshinobu, 2L Okumura, Shunsuke, 2L Onda, Nobuhiko, 95 Ong, Yi Hong, B0, BI Orellana, G., 8C Otsuka, Shimpei, 2H Overchuk, Marta, 4J Pacheco-Soares, Cristina, AF Palacios, R. E., 12 Park, Eun Taek, 5W Paterson, Cheryl, 2Y Peng, Fen, 7T Pereira, Stephen P., 13, 45, 4R, 6K Perry, Alexis, 6R Pinon, A., 9A Pinto, Adenir Ferreira, 8F Pomper, Martin G., 4J Porte, Henri, 2M Potapov, Alexander, 6B Pratavieira, Sebastião, 8K Prates, Renato A., 8F Purtskhvanidze, Violeta, 86 Qiu, Li-Hua, 27 Ramirez-Ramirez, J., A0, A1 Ramírez-San-Juan, JC, A0, A1 Ramos-García, R., A0, A1 Rattanayatikul, Sutthichon, 9L Reburn, Charlotte, 6R Reyns, N., 64 Ribeiro, Martha S., 48, BY Ricci, Ritchelli, AF Rivarola, Viviana Alicia, 12, 3L Rivas, L., 8C Romanishkin, Igor, 6B Romo, C., 8J Rostomyan, Dzhivan, 86 Rumie Vittar, Natalia Belén, 3L Ryabova, Anastasia, 6B Sabino, Caetano P., 48 Sakiyama, Kylze Ikegami, 8F Saleh, Mohamed Abdul Karim, 8F Sancho, P., 45 Sasaki, Ryuta, 6I Sasaki, Takaaki, 2L Savelieva, Tatiana, 6B Savoie, Huguette, 9I Scherpereel, Arnaud, 2M Selbo, P. K., 45 Senge, Mathias O., 9I Shafirstein, Gal, 46 Shi, Wei, 0V Shibutani, Makoto, 95 Shimizu, Kazuhide, 1H Shuin, Taro, 2H Sieroń, Aleksander, A2, A3, B1, B2 Simakov, Yury, 86 Šimůnek, Tomáš, 9M Singh, Kirit, 6E Singh, Rupesh, 1N Singhal, Sunil, B0 Sol, V., 9A Soler, Concepció, 9H Sontikarn, Nattapon, 9L Spezzia-Mazzocco, T., A0, A1 Staumont, D., 3J Steklá, Monika, 9M Stringasci, Mirian Denise, 6Q Su, Juan, 0V Sugawara, Takashi, 1H Sultanbawa, Yasmina, 0O Suprihadi, Arif, A4 Surmei-Pintilie, Ecaterina, 2M Szeimies, R. Markus, 5L Takahashi, Kiwamu, A4 Tamura, Kaoru, 1H Tan, Hui Sun, A4 Tanaka, Tohru, 2H, 6I, A4 Tanaka, Yoji, 1H Teerakapong, Aroon, 9J, 9L Thecua, Elise, 30, 3J, 5L, 5P, 85 Tippayawat, Patcharaporn, 9L Trukhachova, Tatsiana, 37 Tyrrell, Jess, 2Y Uliana, Marciana P., 8K Urlova, A. N., 81 Usuki, Shiro, 6I Vermandel, M., 4Q, 64 Vicentini, Claire, 30, 3J, 5L, 85 Vignion-Dewalle, Anne-Sophie, 30, 3J, 5L, 85 Vollet Filho, José Dirceu, 6Q Wagnières, Georges, BZ Walt, Heinrich, AP Wasielewski, Eric, 2M Williams, N. R., 97 Wood, Mark, 6R Wu, An-Yue, 27 Wuttiruk, Boonsita, 9L Yaghini, Elnaz, 13, 4R Yakavets, Ilya, 1P Yamamoto, Yasushi, 2L Yamashita, Susumu, 95 Yang, Liyun, 23, 73 Yang, QiuYun, 23, 73 Yang, Xiaojing, 7T Yodh, Arjun G., B0 Yoshida, Nana, 2L Yoshida, Ryohei, 2L Yoshida, Toshinori, 95 Zhang, Zihui, 7G Zhao, Shuang, 0V Zhao, Ting-ting, 7X Zhao, ZiYi, 23, 73 Zheng, Gang, 4J Zhu, Timothy C., B0, BI Ziane, L., 3J, 5P Zimčík, Petr, 9M Zorin, Vladimir, 1P Conference CommitteeSymposium Chair
Conference Chair
Conference Program Committee
Session Chairs
IntroductionThese Proceedings are the outcome, in part, of the papers presented at the 17th Biennial International Photodynamic Association (IPA) World Congress held at the Boston Marriot Cambridge Hotel, in Cambridge, MA from June 28 – July 4, 2019. The Congress was forward-looking, projecting areas with high potential for making an impact on healthcare and science using Photodynamic therapy (PDT) & Photodiagnosis (PD), as well as capturing the current state of the field. Both basic science and applied topics were covered and provided a good platform for exchange of ideas between laboratory scientists, clinicians, and engineers. It was specifically aimed to help implement “bench to bedside” translation, and targeted clinical applications for which the optical approach of PDT & PD could provide unique benefits. The Congress was attended by nearly 500 engineers, physicians and scientists and was sponsored by a number of industry partners. Particular emphasis was placed on encouraging attendance by junior scientists, women, and underrepresented minorities in the United States amongst other specialties, so that diverse viewpoints may be presented. Industry was strongly encouraged to participate in order to provide perspective on challenges associated with manufacturing and marketing of related medical drugs and devices. The publications in this issue incorporate diverse topics from PD of thoracic malignancies (Ohsaki et al.) to the use of natural substance photosensitizers such as curcumin (Damyeh et al.). A 200 subjects case study over 10 years on PDT in unresectable cholangiocarcinoma by Park et al. is a valuable write-up on a topic that has been elusive for the PDT community in completing controlled trials. In addition, there was a focus on Low Cost Technologies in PDT and PD for implementation in low to middle income countries in sessions devoted to global health. Paper by Khan et al reflects the use of a smart phone for lesion localization and basis dosimetry. The special roles that photodynamic activation plays in immunology and disinfection of surfaces were important features at the conference, the latter being somewhat new and upcoming. Novel light delivery, sources and dosimetry were an important theme such as ‘Light emitting fabrics for PDT: technology and results of clinical studies’ Mordon et al. The use of biocompatible quantum dots is an emerging area and the paper by Labib et al. discusses the use of these in targeting of epidermal growth factor receptor positive pancreatic cancer cell lines. There are several basic cellular mechanism papers with an overview of death pathways (Kessel) and the discovery of a new iron-chelating prodrug (Reburn et al). Overviews of antimicrobial therapy in general (Ribiero et al.) and in South America in particular (de Frietas et al.) are also important contributions in this edition. Finally, we observed the passing of Thomas J Dougherty by celebrating with a special symposium on the impact he made to the field. The article Thomas J. Dougherty: present at the creation by David Kessel provides an important and an interesting read into the development of PDT. Typically, the conference opened with Plenary Lectures which encompass broad overviews of science and applications of disease. Of note was special lectures by Jack W. Szostak (Harvard Medical School, Massachusetts General Hospital, United States) Nobel laureate in Physiology and Medicine in 2009. Industry leaders from Novartis and Merrimack Pharmaceuticals were also part of the plenary lecture series to provide an overview of challenges in the development of therapeutics and diagnostics. Professor Rakesh Jain from the Massachusetts General Hospital and Harvard Medical School provided the basis of exploiting tumor physiology for developing approaches to novel therapeutics in his plenary lecture. I thank the attendees and our industry partners for their participation in making this a successful Congress and hope that you will enjoy reading the Proceedings. Tayyaba Hasan |
