CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 11070 > Article
Presentation
14 August 2019 Photodynamic nanomedicine synchronizes cytotoxic and molecular therapies to suppress multiple treatment escape pathways (Conference Presentation)
Bryan Q. Spring
Author Affiliations +
Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 110701J (2019) https://doi.org/10.1117/12.2526045
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States
Abstract
This talk will introduce spatiotemporal synchronization of photodynamic therapy (PDT) combined with molecular targeted therapies to suppress multiple treatment escape pathways in parallel. We newly developed photoactivatable multi-inhibitor nanoliposomes (PMILs) for photodynamic tumor cell and microvessel damage in concert with photo-initiation of tumor-confined, multikinase inhibitor release. The PMIL is a biodegradable delivery system for precision medicine comprised of a nanoliposome carrying a photoactivable chromophore in its bilayer. A multikinase inhibitor-loaded PEG-PLGA nanoparticle is encapsulated within the liposome, which acts a barrier to nanoparticle erosion and drug release. Following intravenous PMIL administration, near infrared irradiation of tumors triggers PDT and initiates tumor-confined drug release from the nanoparticle. Preclinical data in mouse models of pancreatic cancer demonstrates that this concept facilitates suppression of the VEGF and MET signaling pathways—both critical to cancer progression, metastasis and treatment escape. Remarkably, a single PMIL treatment using low doses of a multikinase inhibitor (less than 1/1,000th of the standard cumulative dose) achieves sustained tumor reduction and suppresses metastatic escape, whereas combination therapy by co-administration of the individual agents compromises spatiotemporal synchronization and has significantly reduced efficacy. The PMIL concept is amenable to a number of molecular inhibitors and offers new prospects for precise and efficient use of potent but toxic multimolecular targeted therapies, reducing systemic drug exposure and associated toxicities.
Conference Presentation
© (2019) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Bryan Q. Spring "Photodynamic nanomedicine synchronizes cytotoxic and molecular therapies to suppress multiple treatment escape pathways (Conference Presentation)", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110701J (14 August 2019); https://doi.org/10.1117/12.2526045
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Photodynamic therapy
Therapeutics
Tumors
Nanomedicine
Nanoparticles
Pancreatic cancer
Chromophores
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top