Modelling novel PDT approaches to target peripheral lung cancers (Conference Presentation)

Lothar D. Lilge; Christopher McFadden; Khaled Ramadan; Zhangcheng Zheng; Fynn Schwiegelshohn; Vaughn Betz; Marcelo Cypel

doi:10.1117/12.2526056

14 August 2019 Modelling novel PDT approaches to target peripheral lung cancers (Conference Presentation)

Lothar D. Lilge, Christopher McFadden, Khaled Ramadan, Zhangcheng Zheng, Fynn Schwiegelshohn, Vaughn Betz, Marcelo Cypel

Author Affiliations +

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 110704W (2019) https://doi.org/10.1117/12.2526056
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

While the prevalence of central bronchial tumours is declining, that of peripheral lung tumours is increasing. Peripheral lung tumours present either as individual index lesion or as field cancerization, requiring for the former targeting of particular confined volumes of lung tissue versus a therapy for an entire lung or particular lobes thereof. Using FullMonte, a Monte Carlo code; the ability to achieve a tumour selective PDT by transbronchial light source placement was simulated for 525, 665 and 808 nm wavelength. Simulations were executed utilizing in silica models with up to 10 generations of the bronchial tree, tissue photosensitizer concentrations taken from literature or measure in preclinical model systems and tissue optical properties measured with alive ex vivo pig and human lungs perfused with either blood or a transparent low cellular (STEEN) fluid. The measured effective attenuation coefficients [cm-1] at the three wavelengths for ventilated lungs with either blood 1.26±1.07, 1.93±0.534, 1.09±0.93 or STEEN fluid 1.01±0.873, 0.901±0.318, 0.641±0.31 used as perfusate. When modelling the PDT dose distribution in the lung’s the bronchial air ducts up to the eight generations perturb the fluence considerably. In all simulations, a dose sufficient to cause necrosis in 98% of the target volume placement of 3 source fibres albeit with various extent of normal lung tumour damage. Full coverage of an entire lung lobe with only three source fibres placed does not provide for effective coverage of the diffuse disease unless a very high selective uptake of the photosensitizer in malignant tissues can be achieved.

Conference Presentation

Citation Download Citation

Lothar D. Lilge, Christopher McFadden, Khaled Ramadan, Zhangcheng Zheng, Fynn Schwiegelshohn, Vaughn Betz, and Marcelo Cypel "Modelling novel PDT approaches to target peripheral lung cancers (Conference Presentation)", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110704W (14 August 2019); https://doi.org/10.1117/12.2526056

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KEYWORDS

Lung

Photodynamic therapy

Modeling

Lung cancer

Monte Carlo methods

Systems modeling

Blood

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