Implantable electronic device and tissue-adhesive nanosheets can introduce photodynamic therapy into inside the body (Conference Presentation)

Izumi Kirino; Kento Yamagishi; Isao Takahashi; Hizuru Amano; Shinji Takeoka; Shinji Uemoto; Toshinori Fujie; Yuji Morimoto

doi:10.1117/12.2528044

14 August 2019 Implantable electronic device and tissue-adhesive nanosheets can introduce photodynamic therapy into inside the body (Conference Presentation)

Izumi Kirino, Kento Yamagishi, Isao Takahashi, Hizuru Amano, Shinji Takeoka, Shinji Uemoto, Toshinori Fujie, Yuji Morimoto

Author Affiliations +

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 110705C (2019) https://doi.org/10.1117/12.2528044
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

Low-intensity (< 0.1 mW/cm2) yet long-term (> 2-3 days) photodynamic therapy(PDT), termed metronomic photodynamic therapy(mPDT), is attracting attention because of its superior selectivity for malignant tumors and safety for the surrounding normal tissues. Because mPDT requires only a feeble light, the light source can be miniaturized and thus fully implantable in the human body by using the technology of wireless electric power supply. These advantages suggest that mPDT can be applied to the tumors in internal cavities such as the brain, chest, and abdomen. We investigated the anti-tumor effect of mPDT using wirelessly powered fingernail size LED device which was sandwiched by tissue-adhesive nanosheets for suture-free fixation onto the tissue. The devices were implanted subcutaneously beneath small intradermal tumors on the back of mice. Mice moved freely in the cage which was placed on the antenna board for 12 days experimental period. We used photofrin as the photosensitizer, and applied two separate colors of LED devices, red(λ=630nm) and green(λ=530nm), according to light absorbances by photofrin. After ten days of treatment, mouse receiving mPDT achieved significant growth suppression of the tumor compared to the control group which carried non-functional device along with being placed on the antenna board. Unlike conventional PDT which is confined to use red light by optical fibers, mPDT employing green light led even stronger anti-tumor effect than red. These results showed that mPDT using implantable optoelectronic device could be applied to cancers in internal organs as a new treatment strategy.

Conference Presentation

Citation Download Citation

Izumi Kirino, Kento Yamagishi, Isao Takahashi, Hizuru Amano, Shinji Takeoka, Shinji Uemoto, Toshinori Fujie, and Yuji Morimoto "Implantable electronic device and tissue-adhesive nanosheets can introduce photodynamic therapy into inside the body (Conference Presentation)", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110705C (14 August 2019); https://doi.org/10.1117/12.2528044

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Photodynamic therapy

Electronic components

Tissue optics

Tumors

Light emitting diodes

Tissues

Antennas

Show All Keywords

Keywords/Phrases

Search In:

Publication Years