Endoscopic ultrasound and PDT for pancreatic cancer

John DeWitt

doi:10.1117/12.2528591

7 August 2019 Endoscopic ultrasound and PDT for pancreatic cancer

John DeWitt

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 110705Y (2019) https://doi.org/10.1117/12.2528591
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

Background and Aims: In a single-center, prospective, dose-escalation phase 1 study, patients with treatment-naïve locally advanced pancreatic cancer (LAPC) received intravenous porfimer sodium followed 2 days later by EUS-PDT. EUS-PDT was performed by puncture with a 19-gauge needle and insertion of a 1.0-cm light diffuser and illumination with a 630-nm light. A CT scan 18 days after PDT was done to assess for change in pancreatic necrosis. Nab-paclitaxel and gemcitabine were initiated 7 days after CT. Results: Twelve patients (mean age, 67 ± 6 years; 8 male) with tumors (mean diameter, 45.2 ± 12.9 mm) in the head and/or neck (8) or body and/or tail (4) underwent EUS-PDT. Compared with baseline imaging, increased volume and percentage of tumor necrosis were observed in 6 of 12 patients (50%) after EUS-PDT. No serious adverse events from PDT occurred. Conclusion: EUS-PDT for LAPC is technically feasible. Phase II studies are warranted.

Conference Presentation

Citation Download Citation

John DeWitt "Endoscopic ultrasound and PDT for pancreatic cancer", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110705Y (7 August 2019); https://doi.org/10.1117/12.2528591

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