Determination of in-vivo tissue optical properties for anal photodynamic therapy

Andrew C. Li; Yi Hong Ong; Andreea Dimofte; Theresa M. Busch; Timothy C. Zhu

doi:10.1117/12.2525624

7 August 2019 Determination of in-vivo tissue optical properties for anal photodynamic therapy

Andrew C. Li, Yi Hong Ong, Andreea Dimofte, Theresa M. Busch, Timothy C. Zhu

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 11070BI (2019) https://doi.org/10.1117/12.2525624
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

Determination of in-vivo tissue optical properties for anal photodynamic therapy (PDT) is challenging due to the light integrating-sphere effect in an enclosed cylindrical cavity. We developed a model for optical properties determination for anal PDT from measurements of light fluence rate inside a cylindrical cavity submerged in tissue-mimicking liquid phantoms. Measurements are performed in a set of phantoms with known optical properties (μ_a = 0.1-0.9 cm^-1) and (μ_s’ = 5.5-16.5 cm^-1) and the primary and scatter light fluence rates are determined. We developed a forward empirical model to relate scatter light fluence rate measured in an enclosed cylindrical geometry to the surrounding tissue optical properties in tissue-simulating liquid phantoms.

Citation Download Citation

Andrew C. Li, Yi Hong Ong, Andreea Dimofte, Theresa M. Busch, and Timothy C. Zhu "Determination of in-vivo tissue optical properties for anal photodynamic therapy", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 11070BI (7 August 2019); https://doi.org/10.1117/12.2525624

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