Time-resolved near infrared spectroscopy in ischemic stroke patients

Marta Zanoletti; Giacomo Giacalone; Davide Contini; Rebecca Re; Lorenzo Spinelli; Bruno Germinario; Luisa Roveri; Alessandro Torricelli

doi:10.1117/12.2530627

11 July 2019 Time-resolved near infrared spectroscopy in ischemic stroke patients

Marta Zanoletti, Giacomo Giacalone, Davide Contini, Rebecca Re, Lorenzo Spinelli, Bruno Germinario, Luisa Roveri, Alessandro Torricelli

Author Affiliations +

Proceedings Volume 11074, Diffuse Optical Spectroscopy and Imaging VII; 110740T (2019) https://doi.org/10.1117/12.2530627
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

In this paper we present a Time Resolved Near Infrared device for bed-side neuromonitoring of ischemic stroke patients. This system features three wavelengths allowing a better and robust retrieval of the absolute values of oxy and deoxyhaemoglobin. The device has been fully characterized following the guidelines of the MEDPHOT and BIP protocols, developed under NEUROPt project. Time Resolved spectroscopy is a promising technology that can provide reproducible results in terms of absorption and scattering coefficients. This portable and non-invasive system has been proven suitable for operation in clinical settings.
Data were collected from a cohort of 47 ischemic stroke patients and, according to their cerebral impairment, compared with normal values obtained from a group of 35 healthy subjects. Significant differences in haemoglobin species concentration and saturation were found between healthy and ischemic stroke patients. In the ischemic area of both recanalized and non-recanalized ischemic stroke patients, deoxy-haemoglobin and total haemoglobin values are higher than in controls, while tissue oxygen saturation values are lower only in recanalized patients.

Citation Download Citation

Marta Zanoletti, Giacomo Giacalone, Davide Contini, Rebecca Re, Lorenzo Spinelli, Bruno Germinario, Luisa Roveri, and Alessandro Torricelli "Time-resolved near infrared spectroscopy in ischemic stroke patients", Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 110740T (11 July 2019); https://doi.org/10.1117/12.2530627

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KEYWORDS

Ischemic stroke

Near infrared spectroscopy

Absorption

Scattering

Tissues

Brain

Control systems

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