Instrument response function acquisition in reflectance geometry for time-resolved diffuse optical measurements

Ileana Pirovano; Rebecca Re; Davide Contini; Lorenzo Spinelli; Alessandro Torricelli

doi:10.1117/12.2526931

11 July 2019 Instrument response function acquisition in reflectance geometry for time-resolved diffuse optical measurements

Ileana Pirovano, Rebecca Re, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli

Author Affiliations +

Proceedings Volume 11074, Diffuse Optical Spectroscopy and Imaging VII; 110742R (2019) https://doi.org/10.1117/12.2526931
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Time-resolved (TR) techniques are exploited in many biomedical applications in order to find absolute values of absorption (μ_a) and reduced scattering (μ_s’) coefficients that characterize biological tissues chemical and microstructure properties. However, the concomitant acquisition of tissue distribution time-of-flight (DTOF) and instrument response function (IRF) is necessary to perform quantitative measurements. This can be a non-trivial time consuming operation which typically requires to detach the optical fibers from the measurement probe (usually put in a reflectance configuration for in-vivo applications) in order to face them one to each other (“reference” geometry). To overcome these difficulties, a new IRF measurement method that exploit the “reflectance” geometry is here proposed. A practical 3D printed implementation has been carried out for a specific device to test the feasibility of this approach and if the IRF acquired in the “reflectance” geometry is equivalent to the “reference” one. A particular problem addressed is the determination of the temporal shift T0 that can occur between IRF and sample DTOF. Two different approaches, based respectively on the curves barycenters difference and on a calibration phantom, are proposed. Both methods are valid and indifferently applicable according to specific measurement requirements. This allows “reflectance” IRF acquisition to be eligible as standard methodology for TR measurements.

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Ileana Pirovano, Rebecca Re, Davide Contini, Lorenzo Spinelli, and Alessandro Torricelli "Instrument response function acquisition in reflectance geometry for time-resolved diffuse optical measurements", Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 110742R (11 July 2019); https://doi.org/10.1117/12.2526931

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KEYWORDS

Reflectivity

Optical fibers

Photons

Tissues

3D acquisition

Optical testing

3D metrology

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