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19 July 2019 Dual-wavelength nanosecond pulsed-laser using stimulated Raman scattering for fast functional photoacoustic microscopy
Sang Min Park, Soon-Woo Cho, Do Yeon Kim, Sang-Won Lee, Chang-Seok Kim
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Proceedings Volume 11077, Opto-Acoustic Methods and Applications in Biophotonics IV; 110770Y (2019) https://doi.org/10.1117/12.2526915
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany
Abstract
We present a dual-wavelength laser using stimulated Raman scattering (SRS) effect which have high pulse repetition rate for fast functional photoacoustic (PA) imaging. This laser has a high pulse repetition rate of 300 kHz and high pulse energy more than 200 nJ. We periodically modulated the electro-optic modulator voltage from 0 to 168 V to switch the polarization of the output light. Two different pulse lights separated by polarization switching were used to generate different SRS peaks using Raman fibers with lengths of 5 and 20 m. The operating wavelength of this laser was switched to 545 nm and 603 nm using SRS effect and polarization switching. Wavelength dependent fast functional PA images of blood vessels and gold nanorods were obtained using a dual-wavelength switchable SRS pulsed-laser.
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Sang Min Park, Soon-Woo Cho, Do Yeon Kim, Sang-Won Lee, and Chang-Seok Kim "Dual-wavelength nanosecond pulsed-laser using stimulated Raman scattering for fast functional photoacoustic microscopy", Proc. SPIE 11077, Opto-Acoustic Methods and Applications in Biophotonics IV, 110770Y (19 July 2019); https://doi.org/10.1117/12.2526915
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KEYWORDS
Raman scattering
Photoacoustic microscopy
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