Optoacoustic angiography of experimental tumors

Anna Orlova; Marina Sirotkina; Ekaterina Smolina; Vadim Elagin; Ilya Turchin; Pavel Subochev

doi:10.1117/12.2527148

19 July 2019 Optoacoustic angiography of experimental tumors

Anna Orlova, Marina Sirotkina, Ekaterina Smolina, Vadim Elagin, Ilya Turchin, Pavel Subochev

Proceedings Volume 11077, Opto-Acoustic Methods and Applications in Biophotonics IV; 1107711 (2019) https://doi.org/10.1117/12.2527148
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Raster-scan optoacoustic angiography at 532 nm wavelength with 50 μm lateral resolution at 2 mm diagnostic depth was used for quantitative characterization of neoangiogenesis in colon cancer models. Vessels of subcutaneously growing murine colon carcinoma (СT26) was imaged from 5th to 13th day of growth. The values of vascular density were calculated from the optoacoustic data. Inhomogeneous distribution of areas with high and low vascularization was demonstrated in the tumors. During tumor development vessel growth from the periphery to the center of the tumor was shown. Increase of vascular density precedes the increase of tumor volume. The obtained results may be important for the investigation of tumor development and for improvement of cancer treatment strategies.

Citation Download Citation

Anna Orlova, Marina Sirotkina, Ekaterina Smolina, Vadim Elagin, Ilya Turchin, and Pavel Subochev "Optoacoustic angiography of experimental tumors", Proc. SPIE 11077, Opto-Acoustic Methods and Applications in Biophotonics IV, 1107711 (19 July 2019); https://doi.org/10.1117/12.2527148

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