Translator Disclaimer
19 July 2019 Optoacoustic angiography of experimental tumors
Author Affiliations +
Raster-scan optoacoustic angiography at 532 nm wavelength with 50 μm lateral resolution at 2 mm diagnostic depth was used for quantitative characterization of neoangiogenesis in colon cancer models. Vessels of subcutaneously growing murine colon carcinoma (СT26) was imaged from 5th to 13th day of growth. The values of vascular density were calculated from the optoacoustic data. Inhomogeneous distribution of areas with high and low vascularization was demonstrated in the tumors. During tumor development vessel growth from the periphery to the center of the tumor was shown. Increase of vascular density precedes the increase of tumor volume. The obtained results may be important for the investigation of tumor development and for improvement of cancer treatment strategies.
© (2019) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Anna Orlova, Marina Sirotkina, Ekaterina Smolina, Vadim Elagin, Ilya Turchin, and Pavel Subochev "Optoacoustic angiography of experimental tumors", Proc. SPIE 11077, Opto-Acoustic Methods and Applications in Biophotonics IV, 1107711 (19 July 2019);

Back to Top