Observing dynamic changes in articular cartilage birefringence during compression using polarization-sensitive optical coherence tomography

Matthew Goodwin; Ashvin Thambyah; Frédérique Vanholsbeeck

doi:10.1117/12.2524766

19 July 2019 Observing dynamic changes in articular cartilage birefringence during compression using polarization-sensitive optical coherence tomography

Matthew Goodwin, Ashvin Thambyah, Frédérique Vanholsbeeck

Author Affiliations +

Proceedings Volume 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III; 110781N (2019) https://doi.org/10.1117/12.2524766
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Destructuring of the extracellular matrix has been identified as a key factor in the initial stages of cartilage degeneration. The disruption and reorganisation of the collagen network leads to alterations in the materials intrinsic birefringent properties. A recent study showed that healthy bovine cartilage, that has been compressed and fixed, exhibits stronger birefringence than cartilage with early signs of degeneration. In this summary, we use polarization-sensitive optical coherence tomography (PS-OCT) to dynamically extract such optical properties, in real-time, during an established creep loading protocol. Preliminary results provide an insight into the physiological response of collagen fibers which indicate that the observed birefringence is likely due to the middle and deep zone fiber alignment becoming non-parallel with respect to the propagating light. This finding not only helps explain many of the contradictory findings presented in previous studies but also demonstrates that PS-OCT offers a non-destructive and non-invasive method to gain insight into the complex physiology behind cartilage degeneration in a real-time manner.

Citation Download Citation

Matthew Goodwin, Ashvin Thambyah, and Frédérique Vanholsbeeck "Observing dynamic changes in articular cartilage birefringence during compression using polarization-sensitive optical coherence tomography", Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110781N (19 July 2019); https://doi.org/10.1117/12.2524766

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KEYWORDS

Cartilage

Birefringence

Optical coherence tomography

Optical fibers

Collagen

Optical activity

Nondestructive evaluation

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