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A novel optical polarimetry technique for performing non-invasive glucose monitoring is proposed. In the proposed approach, a differential Mueller matrix polarimetry technique is used to extract the optical rotation angle and depolarization index of the sample. The glucose concentration of the sample is detected by sensing the change in the polarization plane of the incident light as it passes through the sample. The feasibility of the proposed technique is demonstrated by measuring the glucose contents of phantom solutions with known glucose concentrations in the range of 0~500 mg/dL by using two different Stokes-Mueller matrix polarimetric measurement systems. The practical applicability of the proposed technique is confirmed by measuring the glucose concentration of mice.
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