Terahertz attenuated total reflection imaging of fresh brain tumor

Limin Wu; Degang Xu; Yuye Wang; Bin Liao; Zhinan Jiang; Meilan Ge; Lu Zhao; Zhongcheng Sun; Sheng Gong; Nan Wu; Tunan Chen; Hua Feng; Jianquan Yao

doi:10.1117/12.2538455

18 November 2019 Terahertz attenuated total reflection imaging of fresh brain tumor

Limin Wu, Degang Xu, Yuye Wang, Bin Liao, Zhinan Jiang, Meilan Ge, Lu Zhao, Zhongcheng Sun, Sheng Gong, Nan Wu, Tunan Chen, Hua Feng, Jianquan Yao

Author Affiliations +

Proceedings Volume 11196, Infrared, Millimeter-Wave, and Terahertz Technologies VI; 111961O (2019) https://doi.org/10.1117/12.2538455
Event: SPIE/COS Photonics Asia, 2019, Hangzhou, China

Abstract

In this paper, we demonstrated that tumors in freshly excised whole brain tissue could be differentiated clearly from normal brain tissue using a homemade continuous terahertz (THz) wave attenuated total reflection (ATR) imaging system. The resolution of this system was about 400μm×450μm at 2.52THz. The terahertz images characters of fresh brains with tumor was studied using this THz-ATR imaging system. Tumor regions could be differentiated clearly from normal brain tissue by THz intensity imaging at different frequencies. The high absorption regions in THz images corresponded well to the tumor regions in the hematoxylin and eosin-stained microscopic images. Moreover, the morphological reconstruction method was applied to restore the blurred imaging results. The noise caused by power fluctuation in THz-ATR image was almost eliminated and the visibility of objects has been successfully enhanced. These promising results suggest that THz-ATR imaging could be used as a tool for label-free and real-time imaging of brain tumors, which would be great potential as an alternative method for the fast diagnosis tumor region during brain surgery.

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Limin Wu, Degang Xu, Yuye Wang, Bin Liao, Zhinan Jiang, Meilan Ge, Lu Zhao, Zhongcheng Sun, Sheng Gong, Nan Wu, Tunan Chen, Hua Feng, and Jianquan Yao "Terahertz attenuated total reflection imaging of fresh brain tumor", Proc. SPIE 11196, Infrared, Millimeter-Wave, and Terahertz Technologies VI, 111961O (18 November 2019); https://doi.org/10.1117/12.2538455

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