Lab-on-fiber SERS substrates for biomolecular recognition

G. Quero; G. Zito; S. Managò; F. Galeotti; M. Pisco; Anna C. De Luca; A. Cusano

doi:10.1117/12.2540651

28 August 2019 Lab-on-fiber SERS substrates for biomolecular recognition

G. Quero, G. Zito, S. Managò, F. Galeotti, M. Pisco, Anna C. De Luca, A. Cusano

Proceedings Volume 11199, Seventh European Workshop on Optical Fibre Sensors; 111991C (2019) https://doi.org/10.1117/12.2540651
Event: Seventh European Workshop on Optical Fibre Sensors, 2019, Limassol, Cyprus

Abstract

We report on our activities related to the development of surface enhanced Raman scattering (SERS) probes realized onto the optical fiber tip (OFT) through nanosphere lithography. In the first stage of our research, we adapted the nanosphere lithography to operate on the optical fiber tip, by assessing the process and demonstrating either the potentiality or the repeatability of the proposed nanopatterning approach. Successively, we investigated the ability of the manufactured structures on the fiber tip to act as SERS probes by measuring the SERS spectra in presence of a Biphenyl Thiol (BPT) monolayer. Firstly, we focused the attention on the samples shaped as closed packed array of nanospheres covered by gold. The analysis allowed us to identify the most promising SERS platform, exhibiting an Enhancement Factor (EF) of 4×10⁵ and a SERS measurements variability lower than 10%. We addressed also the limitations related to the use of the same optical fiber for both illumination and light collection by selecting a commercial optical fiber exhibiting a suitable trade-off in terms of high excitation/collection efficiency and low silica background. Current activities are devoted to the investigation of other nanopatterns on the optical fiber tip (namely, Sparse Array of metallodielectric spheres) and the analysis of the probes response against different molecules.

Citation Download Citation

G. Quero, G. Zito, S. Managò, F. Galeotti, M. Pisco, Anna C. De Luca, and A. Cusano "Lab-on-fiber SERS substrates for biomolecular recognition", Proc. SPIE 11199, Seventh European Workshop on Optical Fibre Sensors, 111991C (28 August 2019); https://doi.org/10.1117/12.2540651

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