Development of drug-loaded magneto-sensitive liposomes investigated by fluorescence techniques

Beatriz D. Cardoso; Daniela S. M. Pereira; A. Rita O. Rodrigues; Paulo J. G. Coutinho; Elisabete M. S. Castanheira

doi:10.1117/12.2527426

3 October 2019 Development of drug-loaded magneto-sensitive liposomes investigated by fluorescence techniques

Beatriz D. Cardoso, Daniela S. M. Pereira, A. Rita O. Rodrigues, Paulo J. G. Coutinho, Elisabete M. S. Castanheira

Proceedings Volume 11207, Fourth International Conference on Applications of Optics and Photonics; 112071R (2019) https://doi.org/10.1117/12.2527426
Event: IV International Conference on Applications of Optics and Photonics (AOP 2019), 2019, Lisbon, Portugal

Abstract

Magneto-sensitive liposomes can be obtained by encapsulation of magnetic nanoparticles into liposomes or by the coverage of magnetic nanoparticles with a lipid bilayer. The so-called magnetoliposomes make possible to explore the synergistic effect between chemotherapy and magnetic hyperthermia in cancer therapeutics. Both aqueous magnetoliposomes (magnetic nanoparticles entrapped in liposomes) and solid magnetoliposomes (clusters of nanoparticles covered by a lipid bilayer), containing biocompatible magnetic nanoparticles, have been developed, exhibiting a superparamagnetic behavior and diameters below 150 nm. These nanosystems were successfully tested as nanocarriers for fluorescent potential antitumor drugs. Drug-loaded magnetoliposomes have shown the ability to interact by fusion with models of biomembranes and to release the antitumor drugs in in vitro assays using human tumor cell lines. Fluorescencebased methodologies, including Förster Resonance Energy Transfer (FRET), emission quenching and fluorescence anisotropy, have been used as valuable tools for this investigation.

Citation Download Citation

Beatriz D. Cardoso, Daniela S. M. Pereira, A. Rita O. Rodrigues, Paulo J. G. Coutinho, and Elisabete M. S. Castanheira "Development of drug-loaded magneto-sensitive liposomes investigated by fluorescence techniques", Proc. SPIE 11207, Fourth International Conference on Applications of Optics and Photonics, 112071R (3 October 2019); https://doi.org/10.1117/12.2527426

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