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A novel polymeric nanoparticle was developed between the negatively charged dendrimer phthalocyanine and positively triblock copolymer for the use as an effective photosensitizer in photodynamic therapy. The intracellular uptake of dendrimer phthalocyanines in HeLa cell was significantly enhanced by encapsulated into nanoparticles. The photocytotoxicity of dendrimer phthalocyanines incorporated into polymeric micelles was also increased. The presence of nanoparticles located induced efficient cell death.
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Kuizhi Chen, Ruotao Guo, Shuanghuang Xiao, Xia Li, Jiao Wang, Yiru Peng, "Dendrimer phthalocyanine based nanoparticles: an effective photosensitizer for enhanced photodynamic therapy," Proc. SPIE 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 1120923 (20 December 2019); https://doi.org/10.1117/12.2547956