Dendrimer phthalocyanine based nanoparticles: an effective photosensitizer for enhanced photodynamic therapy

Kuizhi Chen; Ruotao Guo; Shuanghuang Xiao; Xia Li; Jiao Wang; Yiru Peng

doi:10.1117/12.2547956

20 December 2019 Dendrimer phthalocyanine based nanoparticles: an effective photosensitizer for enhanced photodynamic therapy

Kuizhi Chen, Ruotao Guo, Shuanghuang Xiao, Xia Li, Jiao Wang, Yiru Peng

Author Affiliations +

Proceedings Volume 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019); 1120923 (2019) https://doi.org/10.1117/12.2547956
Event: Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 2019, Xi'an, China

Abstract

A novel polymeric nanoparticle was developed between the negatively charged dendrimer phthalocyanine and positively triblock copolymer for the use as an effective photosensitizer in photodynamic therapy. The intracellular uptake of dendrimer phthalocyanines in HeLa cell was significantly enhanced by encapsulated into nanoparticles. The photocytotoxicity of dendrimer phthalocyanines incorporated into polymeric micelles was also increased. The presence of nanoparticles located induced efficient cell death.

Citation Download Citation

Kuizhi Chen, Ruotao Guo, Shuanghuang Xiao, Xia Li, Jiao Wang, and Yiru Peng "Dendrimer phthalocyanine based nanoparticles: an effective photosensitizer for enhanced photodynamic therapy", Proc. SPIE 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 1120923 (20 December 2019); https://doi.org/10.1117/12.2547956

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