Two photon luminescence of gold nanorods with breast cancer cells

Xiang Sang; Kexin Wang; Shuanghuang Xiao; Hongqin Yang; Yiru Peng; Shusen Xie; Jianling Chen

doi:10.1117/12.2549452

20 December 2019 Two photon luminescence of gold nanorods with breast cancer cells

Xiang Sang, Kexin Wang, Shuanghuang Xiao, Hongqin Yang, Yiru Peng, Shusen Xie, Jianling Chen

Proceedings Volume 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019); 1120945 (2019) https://doi.org/10.1117/12.2549452
Event: Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 2019, Xi'an, China

Abstract

Gold nanorods have special optical properties, good biological compatibility and easy preparation, making them have broad application prospects in drug carriers and medical imaging. In this paper, the two photon luminescence of silica modified gold nanorods incubated with different subtypes of breast cancer cells was observed. We demonstrate the effects of different subtypes breast cancer cells on cellular uptake of gold nanorods. And The results show that significant decreases internalization of gold nanorods with the presence of fetal bovine serum protein in cell culture. Two-photon imaging revealed that cellular uptake of gold nanorods was affected by serum and subtypes of cells, and movement of gold nanorods in the cells was observed. Our findings can provide useful information for medical imaging of gold nanorods in biomedical application.

Citation Download Citation

Xiang Sang, Kexin Wang, Shuanghuang Xiao, Hongqin Yang, Yiru Peng, Shusen Xie, and Jianling Chen "Two photon luminescence of gold nanorods with breast cancer cells", Proc. SPIE 11209, Eleventh International Conference on Information Optics and Photonics (CIOP 2019), 1120945 (20 December 2019); https://doi.org/10.1117/12.2549452

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