Clinical applicability of in vivo harmonic generation microscopy for the diagnosis and grading of actinic keratosis (Conference Presentation)

Chi-Kuang Sun; Yi Pan; Pei-Che Wu; Sheng-Tse Chen; Yi-Hua Liao

doi:10.1117/12.2541484

6 March 2020 Clinical applicability of in vivo harmonic generation microscopy for the diagnosis and grading of actinic keratosis (Conference Presentation)

Chi-Kuang Sun, Yi Pan, Pei-Che Wu, Sheng-Tse Chen, Yi-Hua Liao

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Proceedings Volume 11211, Photonics in Dermatology and Plastic Surgery 2020; 1121107 (2020) https://doi.org/10.1117/12.2541484
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Actinic keratosis (AK) is a common cutaneous neoplasm resulting from severe solar damage. Noninvasive diagnosis and grading of AK are important not just because of AK’s precancerous nature, but also due to the frequent presence of multiple AKs. Here we study the clinical applicability of in vivo harmonic generation microscopy (HGM) for the grading, diagnosis, and treatment assessment of AKs. As a result, 100% agreement on diagnosis and grading outcomes between HGM and traditional histopathology were obtained. Our study indicates the superior capability of in vivo HGM for diagnosis, grading, and treatment assessment of AKs.

Conference Presentation

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Chi-Kuang Sun, Yi Pan, Pei-Che Wu, Sheng-Tse Chen, and Yi-Hua Liao "Clinical applicability of in vivo harmonic generation microscopy for the diagnosis and grading of actinic keratosis (Conference Presentation)", Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 1121107 (6 March 2020); https://doi.org/10.1117/12.2541484

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KEYWORDS

In vivo imaging

Harmonic generation

Microscopy

Confocal microscopy

Optical coherence tomography

Skin

Tissue optics

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