Clinical multimodal multiphoton tomography of pigmented skin lesions with an ultracompact femtosecond fiber laser

Karsten König; Ana Batista; Michael Zieger; Martin Kaatz; Holger Hänssle; Christine Fink; Hans Georg Breunig

doi:10.1117/12.2542322

24 February 2020 Clinical multimodal multiphoton tomography of pigmented skin lesions with an ultracompact femtosecond fiber laser

Karsten König, Ana Batista, Michael Zieger, Martin Kaatz, Holger Hänssle, Christine Fink, Hans Georg Breunig

Author Affiliations +

Proceedings Volume 11211, Photonics in Dermatology and Plastic Surgery 2020; 112110E (2020) https://doi.org/10.1117/12.2542322
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Multiphoton tomography (MPT) has become a high-resolution label-free clinical imaging tool to obtain optical skin biopsies for rapid in vivo histology. Here, we report on the novel multimodal multiphoton tomograph MPT compact based on a chiller-free ultracompact 80 MHz femtosecond fiber laser operating at 780 nm. The 360°-measurement head contains the laser head and multiple photon detectors for (i) autofluorescence (AF) imaging, (ii) fluorescence lifetime imaging (FLIM) for optical metabolic imaging (OMI) and melanin detection, (iii) second harmonic imaging (SHG) of collagen, (iv) confocal reflection microscopy (CRM), and (v) white-light imaging (dermoscopy). Preliminary results of an ongoing multicenter clinical study in patients with suspicious pigmented lesions in two hospitals are presented.

Citation Download Citation

Karsten König, Ana Batista, Michael Zieger, Martin Kaatz, Holger Hänssle, Christine Fink, and Hans Georg Breunig "Clinical multimodal multiphoton tomography of pigmented skin lesions with an ultracompact femtosecond fiber laser", Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 112110E (24 February 2020); https://doi.org/10.1117/12.2542322

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available