Precise closure of single blood vessels via multiphoton photothermolysis (Conference Presentation)

Yimei Huang; Zhenguo Wu; Harvey Lui; Jianhua Zhao; Shusen Xie; Haishan Zeng

doi:10.1117/12.2550983

6 March 2020 Precise closure of single blood vessels via multiphoton photothermolysis (Conference Presentation)

Yimei Huang, Zhenguo Wu, Harvey Lui, Jianhua Zhao, Shusen Xie, Haishan Zeng

Proceedings Volume 11211, Photonics in Dermatology and Plastic Surgery 2020; 112110J (2020) https://doi.org/10.1117/12.2550983
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We report a novel approach to selectively close single blood vessels within tissue using multiphoton absorption-based photothermolysis. The treatment process is monitored by in vivo reflectance confocal microscopy in real-time. Closure of single targeted vessels of varying sizes ranging from capillaries to venules was demonstrated. We also demonstrated that deeply situated vessels could be closed precisely while preserving adjacent overlying superficial vessels. Partial vessel occlusion could also be achieved, and it is accompanied by intravascular blood cell speed increasing. This approach provides a novel precision medicine method for non-invasive precise microsurgery treatment of vascular diseases on per vessel/per lesion basis.

Conference Presentation

Citation Download Citation

Yimei Huang, Zhenguo Wu, Harvey Lui, Jianhua Zhao, Shusen Xie, and Haishan Zeng "Precise closure of single blood vessels via multiphoton photothermolysis (Conference Presentation)", Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 112110J (6 March 2020); https://doi.org/10.1117/12.2550983

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