Analysis diffusion and glycation rate of artery in high concentration sugar condition via autofluorescence of advanced glycation end productions

Chih-Ju Lin; Jeon Woong Kang; Peter T. C. So; Chen-Yuan Dong

doi:10.1117/12.2545589

25 February 2020 Analysis diffusion and glycation rate of artery in high concentration sugar condition via autofluorescence of advanced glycation end productions

Chih-Ju Lin, Jeon Woong Kang, Peter T. C. So, Chen-Yuan Dong

Author Affiliations +

Proceedings Volume 11215, Diagnostic and Therapeutic Applications of Light in Cardiology 2020; 112150D (2020) https://doi.org/10.1117/12.2545589
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Cardiovascular complication is a major health concern for diabetic patients. Elevated blood sugar levels lead to the formation of advanced glycation end products (AGEs), which are implicated in diabetic pathogenesis. In this study, we investigate the effect of prolonged exposure to elevated sugar level by studying the combined effect of diffusion and glycation rate in arteries from different commonly-consumed simple sugars. Since some AGEs are autofluorescent, we will perform multiphoton autofluorescence imaging to quantify the rates of fluorescent AGEs formation in elastic fibers and collagen fibers. Cross-section imaging of arteries and spatial and temporal profiles of autofluorescence of the blood vessel will be investigated.

Conference Presentation

Citation Download Citation

Chih-Ju Lin, Jeon Woong Kang, Peter T. C. So, and Chen-Yuan Dong "Analysis diffusion and glycation rate of artery in high concentration sugar condition via autofluorescence of advanced glycation end productions", Proc. SPIE 11215, Diagnostic and Therapeutic Applications of Light in Cardiology 2020, 112150D (25 February 2020); https://doi.org/10.1117/12.2545589

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