9 March 2020Label-free Raman spectroscopy to study radiation-induced biomolecular changes in animal model of head and neck cancer (Conference Presentation)
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
We have used Raman spectroscopy to assess biomolecular changes of two human head and neck cancer xenografts in response to radiation therapy. We injected radiation-sensitive UM-SCC-22B and –resistant UM-SCC-47 cell lines into the flanks of 80 mice to grow tumor xenografts. Animals were distributed into control and radiation groups where the latter group received a single dose of 2 Gy. In vivo Raman spectroscopy was conducted before, 1, 24, and 48 hours after radiation and data were decomposed using principal component analysis and multi variate curve resolution. We found statistically significant differences in biomolecular changes among radiation-sensitive and –resistant groups.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The alert did not successfully save. Please try again later.
Sina Dadgar, Joel Rodríguez Troncoso, April F. Jules, Austin R. Dotson, Narasimhan Rajaram, "Label-free Raman spectroscopy to study radiation-induced biomolecular changes in animal model of head and neck cancer (Conference Presentation)," Proc. SPIE 11216, Multiscale Imaging and Spectroscopy, 112160O (9 March 2020); https://doi.org/10.1117/12.2546673