Cherenkov imaging to quantify radiation dose in human tissue (Conference Presentation)

Brian W. Pogue

doi:10.1117/12.2551017

9 March 2020 Cherenkov imaging to quantify radiation dose in human tissue (Conference Presentation)

Brian W. Pogue

Proceedings Volume 11216, Multiscale Imaging and Spectroscopy; 112160Q (2020) https://doi.org/10.1117/12.2551017
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Irradiation of tissue causes delivery of dose to the volume, which causes widespread damage, the most important being production of radical oxygen species and the associated DNA damage. Part of the dose deposition is from soft electron collisions, which result in Cherenkov light emission from the relativistic dielectric interaction. This visible light emission is produced at the level of hundreds of photons per x-ray photon, and is significant enough to be detected with single photon imaging cameras. Radiation dosimetry with these cameras is now possible, providing a non-contact way to detect radiation dose deposition in cancer therapy. The demonstration of this imaging methodology and the theoretical underpinnings will be illustrated.

Conference Presentation

Citation Download Citation

Brian W. Pogue "Cherenkov imaging to quantify radiation dose in human tissue (Conference Presentation)", Proc. SPIE 11216, Multiscale Imaging and Spectroscopy, 112160Q (9 March 2020); https://doi.org/10.1117/12.2551017

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KEYWORDS

Tissues

Cameras

Photons

Dielectrics

Oxygen

Radiation dosimetry

Single photon

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