Adaptive optics line-scan OCT for high-speed imaging of retinal structure and function (Conference Presentation)

Vimal Prabhu Pandiyan; Aiden M. Bertelli; James Kuchenbecker; Kevin C. Boyle; Tong Ling; B. Hyle Park; Daniel Palanker; Austin Roorda; Ramkumar Sabesan

doi:10.1117/12.2545204

9 March 2020 Adaptive optics line-scan OCT for high-speed imaging of retinal structure and function (Conference Presentation)

Vimal Prabhu Pandiyan, Aiden M. Bertelli, James Kuchenbecker, Kevin C. Boyle, Tong Ling, B. Hyle Park, Daniel Palanker, Austin Roorda, Ramkumar Sabesan

Author Affiliations +

Proceedings Volume 11218, Ophthalmic Technologies XXX; 1121812 (2020) https://doi.org/10.1117/12.2545204
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We developed a high-speed adaptive optics, line-scan spectral domain OCT and used it to characterize stimulus-induced optical path length changes in cones with high spatiotemporal resolution. We find that individual cone outer segments exhibit a biphasic light-induced response—a rapid axial shrinkage followed by a gradual increase in optical path length, both increasing in magnitude with the stimulus intensity. AO line-scan OCT thus offers high-speed volume acquisitions, high phase stability, sub-ms temporal resolution and cellular-scale spatial resolution, that together enable imaging retinal structure and function in health and disease.

Conference Presentation

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Vimal Prabhu Pandiyan, Aiden M. Bertelli, James Kuchenbecker, Kevin C. Boyle, Tong Ling, B. Hyle Park, Daniel Palanker, Austin Roorda, and Ramkumar Sabesan "Adaptive optics line-scan OCT for high-speed imaging of retinal structure and function (Conference Presentation)", Proc. SPIE 11218, Ophthalmic Technologies XXX, 1121812 (9 March 2020); https://doi.org/10.1117/12.2545204

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KEYWORDS

Optical coherence tomography

Adaptive optics

Line scan image sensors

Cones

High speed imaging

Coherence imaging

In vivo imaging

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