Estimating retinal vascular permeability from fluorescein videoangiography data despite signal saturation in large vessels in low-dynamic range systems

Elif Kayaalp Nalbant; Wenqiang Liu; Hande Pehlivan; Shailee Shah; Anessa Puskar; Meghna Sampath; William F. Mieler; Jennifer J. Kang-Mieler; Kenneth M. Tichauer

doi:10.1117/12.2546442

19 February 2020 Estimating retinal vascular permeability from fluorescein videoangiography data despite signal saturation in large vessels in low-dynamic range systems

Elif Kayaalp Nalbant, Wenqiang Liu, Hande Pehlivan, Shailee Shah, Anessa Puskar, Meghna Sampath, William F. Mieler, Jennifer J. Kang-Mieler, Kenneth M. Tichauer

Author Affiliations +

Proceedings Volume 11218, Ophthalmic Technologies XXX; 1121823 (2020) https://doi.org/10.1117/12.2546442
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Fluorescein videoangiography is often used to visualize diabetic retinopathy (DR), a degenerative disease characterized by degradation of retinal blood vessels. However, more sensitive and quantitative measures of increased vessel permeability in the asymptomatic phase of DR (non-proliferative DR) could help identify patients who would benefit from therapeutic intervention to avoid vision loss. Here, a modified “adiabatic approximation to the tissue-homogeneity model” was shown in simulations and rat experiments to estimate extraction fraction within a 20%-error for physiological ranges of vascular permeability expected in nonproliferative DR, even in low-dynamic-range (8-bit) fluorescein imaging systems that are standard in many institutes.

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Elif Kayaalp Nalbant, Wenqiang Liu, Hande Pehlivan, Shailee Shah, Anessa Puskar, Meghna Sampath, William F. Mieler, Jennifer J. Kang-Mieler, and Kenneth M. Tichauer "Estimating retinal vascular permeability from fluorescein videoangiography data despite signal saturation in large vessels in low-dynamic range systems", Proc. SPIE 11218, Ophthalmic Technologies XXX, 1121823 (19 February 2020); https://doi.org/10.1117/12.2546442

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