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10 March 2020 Photoinactivation of otopathogens using 405 nm blue light: Implications for the treatment of otitis media (Conference Presentation)
Xiaojing Liu, Qihang Chang, Raquel Ferrer-Espada, Leon G. Leanse, Xueping S. Goh, Xiuli Wang, Jeffrey A. Gelfand, Tianhong Dai
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Proceedings Volume 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020; 112230N (2020) https://doi.org/10.1117/12.2546695
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Otopathogens such as Moraxella Catarrhalis and Haemophilus influenzae are the major causes of pediatric chronic and recurrent otitis media (OM). This pilot study showed that both M. catarrhalis and H. influenzae were highly susceptible to antimicrobial blue light (aBL) inactivation at 405 nm, either in suspensions and biofilms. Transmission electron microscopy showed aBL-induced damage of cell membrane in M. catarrhalis cells. Ultra-performance liquid chromatography results revealed that protoporphyrin IX and coproporphyrin are the most abundant species of endogenous porphyrins in M. catarrhalis. Our findings suggest that aBL is potentially an effective alternative antimicrobial therapy for OM.
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Xiaojing Liu, Qihang Chang, Raquel Ferrer-Espada, Leon G. Leanse, Xueping S. Goh, Xiuli Wang, Jeffrey A. Gelfand, and Tianhong Dai "Photoinactivation of otopathogens using 405 nm blue light: Implications for the treatment of otitis media (Conference Presentation)", Proc. SPIE 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020, 112230N (10 March 2020); https://doi.org/10.1117/12.2546695
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KEYWORDS
Transmission electron microscopy
Animal model studies
Chromatography
Liquids
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