Distinct targets for blue light photoinactivation (Conference Presentation)

Carolina dos Anjos; Fabio C. Pogliani; Fábio P. Sellera; Maurício Baptista; Martha S. Ribeiro; Nilton Lincopan; Milena Dropa; Caetano Sabino

doi:10.1117/12.2547336

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10 March 2020 Distinct targets for blue light photoinactivation (Conference Presentation)

Carolina dos Anjos, Fabio C. Pogliani, Fábio P. Sellera, Maurício Baptista, Martha S. Ribeiro, Nilton Lincopan, Milena Dropa, Caetano Sabino

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Proceedings Volume 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020; 112230O (2020) https://doi.org/10.1117/12.2547336
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Our aim was to evaluate membrane integrity and the occurrence of possible DNA damage caused by blue light inactivation. We used in our study three bacterial pathogens with distinct biochemical and morphological characteristics: Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. Through electrophoresis and fluorescence spectroscopy analysis we observed distinct molecular damage between the evaluated microorganisms. Thus, our results suggest distinct mechanisms of inactivation by light blue among different pathogen species. Individual biochemical characteristics of each microorganism may be responsible for the occurrence of distinct structural damage

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Carolina dos Anjos, Fabio C. Pogliani, Fábio P. Sellera, Maurício Baptista, Martha S. Ribeiro, Nilton Lincopan, Milena Dropa, and Caetano Sabino "Distinct targets for blue light photoinactivation (Conference Presentation)", Proc. SPIE 11223, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2020, 112230O (10 March 2020); https://doi.org/10.1117/12.2547336

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