longitudinal multimodal mapping of neural activity and blood flow reveals neurovascular dissociations in an awake mouse model of microinfarcts (Conference Presentation)

Fei He; Colin Sullender; Hanlin Zhu; Theresa Jones; Chong Xie; Andrew K. Dunn; Lan Luan

doi:10.1117/12.2546187

9 March 2020 longitudinal multimodal mapping of neural activity and blood flow reveals neurovascular dissociations in an awake mouse model of microinfarcts (Conference Presentation)

Fei He, Colin Sullender, Hanlin Zhu, Theresa Jones, Chong Xie, Andrew K. Dunn, Lan Luan

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Proceedings Volume 11226, Neural Imaging and Sensing 2020; 1122618 (2020) https://doi.org/10.1117/12.2546187
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Neurovascular coupling, the close spatial and temporal relationship between neural activity and hemodynamics, is disrupted in pathological brain states. To understand the altered neurovascular relationship in abnormal brain states, longitudinal, simultaneous mapping of neural activity and hemodynamics is highly desired but challenging to achieve. Here, we report the development of a multimodal neural platform that realize long-term, spatially-resolved tracking of intracortical neural activity and cerebral blood flow in the same brain regions. We demonstrate the powerful application of this multimodal platform in a mouse model of microinfarcts and reveal a pronounced, long-lasting neurovascular dissociation that depends on the ischemic severity.

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Fei He, Colin Sullender, Hanlin Zhu, Theresa Jones, Chong Xie, Andrew K. Dunn, and Lan Luan "longitudinal multimodal mapping of neural activity and blood flow reveals neurovascular dissociations in an awake mouse model of microinfarcts (Conference Presentation)", Proc. SPIE 11226, Neural Imaging and Sensing 2020, 1122618 (9 March 2020); https://doi.org/10.1117/12.2546187

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KEYWORDS

Brain mapping

Mouse models

Blood circulation

Brain

Cerebral blood flow

Hemodynamics

Imaging systems

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