Detection of cortical optical changes during seizure activity using optical coherence tomography (Conference Presentation)

Danielle Ornelas; Md. Hasan; Jenny Szu; Oscar Gonzalez; Timothy Myers; Koji Hirota; Melissa Eberle; Maksim Bazhenov; Devin Binder; B. Hyle Park

doi:10.1117/12.2546560

9 March 2020 Detection of cortical optical changes during seizure activity using optical coherence tomography (Conference Presentation)

Danielle Ornelas, Md. Hasan, Jenny Szu, Oscar Gonzalez, Timothy Myers, Koji Hirota, Melissa Eberle, Maksim Bazhenov, Devin Binder, B. Hyle Park

Author Affiliations +

Proceedings Volume 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV; 112280O (2020) https://doi.org/10.1117/12.2546560
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Optical coherence tomography (OCT) is a label-free, high resolution, and minimally invasive imaging technique that can produce depth-resolved cross-sectional and 3D images. We sought to examine non-vascular depth-dependent optical changes directly related to neural activity in the brain using OCT. Results of this study show a significant temporal correlation between non-vascular decrease in attenuation in ex vivo and in vivo seizure models and increased electrical activity during seizure. This study allows for a more thorough and biologically relevant analysis of the optical signature of seizure activity ex vivo and in vivo using OCT.

Conference Presentation

Citation Download Citation

Danielle Ornelas, Md. Hasan, Jenny Szu, Oscar Gonzalez, Timothy Myers, Koji Hirota, Melissa Eberle, Maksim Bazhenov, Devin Binder, and B. Hyle Park "Detection of cortical optical changes during seizure activity using optical coherence tomography (Conference Presentation)", Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112280O (9 March 2020); https://doi.org/10.1117/12.2546560

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE