Smartphone-based measurement of serum phosphate levels for patients with kidney disease (Conference Presentation)

Aniruddha Ray; Sarah Esparza; Dimei Wu; Mark Hanudel; Hyou-Arm Joung; Barbara Gales; Isidro Salusky; Aydogan Ozcan

doi:10.1117/12.2547901

9 March 2020 Smartphone-based measurement of serum phosphate levels for patients with kidney disease (Conference Presentation)

Aniruddha Ray, Sarah Esparza, Dimei Wu, Mark Hanudel, Hyou-Arm Joung, Barbara Gales, Isidro Salusky, Aydogan Ozcan

Author Affiliations +

Proceedings Volume 11230, Optics and Biophotonics in Low-Resource Settings VI; 1123009 (2020) https://doi.org/10.1117/12.2547901
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Monitoring serum phosphate level is critical for patients with kidney disease and those undergoing dialysis. We report a POC serum phosphate measurement device, by integrating a disposable paper-based microfluidic chip with a smartphone-based measurement system. The inexpensive microfluidic chip collects a droplet of blood from the patient and isolates the serum, which then reacts with a malachite green reagent, resulting in a colorimetric change, measured using a smartphone-based device. This POC instrument was tested on clinical samples obtained from patients undergoing dialysis, and we observed a strong statistical correlation between our results and the tests performed in a clinical laboratory.

Conference Presentation

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Aniruddha Ray, Sarah Esparza, Dimei Wu, Mark Hanudel, Hyou-Arm Joung, Barbara Gales, Isidro Salusky, and Aydogan Ozcan "Smartphone-based measurement of serum phosphate levels for patients with kidney disease (Conference Presentation)", Proc. SPIE 11230, Optics and Biophotonics in Low-Resource Settings VI, 1123009 (9 March 2020); https://doi.org/10.1117/12.2547901

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