PDMS-based Bragg diffraction grating glucose sensor integrable in a contact lens

Carla Dumitrascu; Maria Morant; Laura Mercadé; Todora Angelova; Roberto Llorente

doi:10.1117/12.2544876

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20 February 2020 PDMS-based Bragg diffraction grating glucose sensor integrable in a contact lens

Carla Dumitrascu, Maria Morant, Laura Mercadé, Todora Angelova, Roberto Llorente

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Proceedings Volume 11233, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XX; 112330Q (2020) https://doi.org/10.1117/12.2544876
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

This paper proposes a glucose optical biosensor based on a Bragg diffraction grating fabricated in Poly(dimethylsiloxane) (or PDMS), suitable for integration in an ophthalmologic contact lens. One of the periodic layers of the grating is functionalized with Glucose Oxidase (GOx) to change its refractive index proportionally with glucose concentration and, therefore, modify the response of the resulting filter. Different layers are fabricated and characterized by spectroscopic ellipsometry considering different glucose concentrations. The proposed structure can detect changes in glucose levels from 80 mg/dl to 180 mg/dl, reducing its optical response to 65% at 521 nm, being capable of real-time, continuous and non-invasive sensing.

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Carla Dumitrascu, Maria Morant, Laura Mercadé, Todora Angelova, and Roberto Llorente "PDMS-based Bragg diffraction grating glucose sensor integrable in a contact lens", Proc. SPIE 11233, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XX, 112330Q (20 February 2020); https://doi.org/10.1117/12.2544876

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